Glutathione Reductase Promotes Fungal Clearance and Suppresses Inflammation during Systemic


Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 10 2019
Historique:
received: 06 12 2017
accepted: 07 08 2019
pubmed: 11 9 2019
medline: 23 5 2020
entrez: 11 9 2019
Statut: ppublish

Résumé

Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in redox regulation. We have previously shown that Gsr facilitates neutrophil bactericidal activities and is pivotal for host defense against bacterial pathogens. However, it is unclear whether Gsr is required for immune defense against fungal pathogens. It is also unclear whether Gsr plays a role in immunological functions outside of neutrophils during immune defense. In this study, we report that

Identifiants

pubmed: 31501257
pii: jimmunol.1701686
doi: 10.4049/jimmunol.1701686
pmc: PMC6783371
mid: NIHMS1536991
doi:

Substances chimiques

Glutathione Reductase EC 1.8.1.7

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2239-2251

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI142885
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121196
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124029
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI090901
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123253
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI113930
Pays : United States

Informations de copyright

Copyright © 2019 by The American Association of Immunologists, Inc.

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Auteurs

Victoria Y Kim (VY)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.

Abel Batty (A)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.

Jinhui Li (J)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.

Sean G Kirk (SG)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.

Sara A Crowell (SA)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.

Yi Jin (Y)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.

Juan Tang (J)

Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210.

Jian Zhang (J)

Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.

Lynette K Rogers (LK)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205; and.

Han-Xiang Deng (HX)

Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

Leif D Nelin (LD)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215.
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205; and.

Yusen Liu (Y)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215; yusen.liu@nationwidechildrens.org.
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205; and.

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