Archangelolide: A sesquiterpene lactone with immunobiological potential from
anti-inflammatory properties
archangelolide
dansyl fluorescent conjugate
sarco/endoplasmic reticulum calcium ATPase
sesquiterpene lactone
trilobolide analogue
Journal
Beilstein journal of organic chemistry
ISSN: 1860-5397
Titre abrégé: Beilstein J Org Chem
Pays: Germany
ID NLM: 101250746
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
05
2019
accepted:
30
07
2019
entrez:
11
9
2019
pubmed:
11
9
2019
medline:
11
9
2019
Statut:
epublish
Résumé
Sesquiterpene lactones are secondary plant metabolites with sundry biological effects. In plants, they are synthesized, among others, for pesticidal and antimicrobial effects. Two such compounds, archangelolide and trilobolide of the guaianolide type, are structurally similar to the well-known and clinically tested lactone thapsigargin. While trilobolide has already been studied by us and others, there are only scarce reports on the biological activity of archangelolide. Here we present the preparation of its fluorescent derivative based on a dansyl moiety using azide-alkyne Huisgen cycloaddition having obtained the two sesquiterpene lactones from the seeds of
Identifiants
pubmed: 31501660
doi: 10.3762/bjoc.15.189
pmc: PMC6720059
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1933-1944Références
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