Considerations for Strategic Use of High-Throughput Transcriptomics Chemical Screening Data in Regulatory Decisions.
Journal
Current opinion in toxicology
ISSN: 2468-2934
Titre abrégé: Curr Opin Toxicol
Pays: Netherlands
ID NLM: 101697847
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
11
9
2019
pubmed:
11
9
2019
medline:
11
9
2019
Statut:
ppublish
Résumé
Recently, numerous organizations, including governmental regulatory agencies in the U.S. and abroad, have proposed using data from New Approach Methodologies (NAMs) for augmenting and increasing the pace of chemical assessments. NAMs are broadly defined as any technology, methodology, approach or combination thereof that can be used to provide information on chemical hazard and risk assessment that avoids the use of intact animals. High-throughput transcriptomics (HTTr) is a type of NAM that uses gene expression profiling as an endpoint for rapidly evaluating the effects of large numbers of chemicals on
Identifiants
pubmed: 31501805
doi: 10.1016/j.cotox.2019.05.004
pmc: PMC6733036
mid: NIHMS1537368
doi:
Types de publication
Journal Article
Langues
eng
Pagination
64-75Subventions
Organisme : Intramural EPA
ID : EPA999999
Pays : United States
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