Role of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature.
Alpha-2-microglobulin
Osteoarthritis
Platelet-rich plasma
Proteinase
Journal
Current pain and headache reports
ISSN: 1534-3081
Titre abrégé: Curr Pain Headache Rep
Pays: United States
ID NLM: 100970666
Informations de publication
Date de publication:
09 09 2019
09 09 2019
Historique:
entrez:
11
9
2019
pubmed:
11
9
2019
medline:
31
3
2020
Statut:
epublish
Résumé
Chronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PRP). Alpha-2-microglobulin, a 720-kD protein complex, is an active protease inhibitor with tremendous anti-inflammatory properties in animal models. A growing body of evidence suggests that this complex is the most instrumental factor for cartilage preservation in PRP injections. As an active component of platelet-rich plasma's anti-inflammatory properties, alpha-2-microglobulin has been shown to be an active inhibitor of joint degeneration, cartilage preservation, and improvement in quality of life for patients with knee osteoarthritis compared with a multitude of other modalities.
Identifiants
pubmed: 31502073
doi: 10.1007/s11916-019-0822-9
pii: 10.1007/s11916-019-0822-9
doi:
Substances chimiques
Alpha-Globulins
0
alpha(2)-microglobulin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
82Commentaires et corrections
Type : ErratumIn
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