Role of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature.


Journal

Current pain and headache reports
ISSN: 1534-3081
Titre abrégé: Curr Pain Headache Rep
Pays: United States
ID NLM: 100970666

Informations de publication

Date de publication:
09 09 2019
Historique:
entrez: 11 9 2019
pubmed: 11 9 2019
medline: 31 3 2020
Statut: epublish

Résumé

Chronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PRP). Alpha-2-microglobulin, a 720-kD protein complex, is an active protease inhibitor with tremendous anti-inflammatory properties in animal models. A growing body of evidence suggests that this complex is the most instrumental factor for cartilage preservation in PRP injections. As an active component of platelet-rich plasma's anti-inflammatory properties, alpha-2-microglobulin has been shown to be an active inhibitor of joint degeneration, cartilage preservation, and improvement in quality of life for patients with knee osteoarthritis compared with a multitude of other modalities.

Identifiants

pubmed: 31502073
doi: 10.1007/s11916-019-0822-9
pii: 10.1007/s11916-019-0822-9
doi:

Substances chimiques

Alpha-Globulins 0
alpha(2)-microglobulin 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

82

Commentaires et corrections

Type : ErratumIn

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Auteurs

Vwaire Orhurhu (V)

Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA. Vwo569@mail.harvard.edu.

Ruben Schwartz (R)

Department of Anesthesiology, Mount Sinai Medical Center of Florida, Miami, FL, USA.

Jacob Potts (J)

Department of Bioengineering, Northeastern University, Boston, MA, USA.

Jacqueline Peck (J)

Department of Anesthesiology, Mount Sinai Medical Center of Florida, Miami, FL, USA.

Ivan Urits (I)

Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

Mariam Salisu Orhurhu (MS)

Departments of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Charles Odonkor (C)

Department of Anesthesia, Critical Care and Pain Medicine, Division of Pain, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Omar Viswanath (O)

Valley Anesthesiology and Pain Consultants, Phoenix, AZ, USA.
Department of Anesthesiology, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
Department of Anesthesiology, Creighton University School of Medicine, Omaha, NE, USA.

Alan Kaye (A)

Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Jatinder Gill (J)

Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

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Classifications MeSH