Statin Use and Knee Osteoarthritis Outcome Measures according to the Presence of Heberden Nodes: Results from the Osteoarthritis Initiative.

Aged Disease Progression Exostoses / diagnostic imaging Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Longitudinal Studies Male Middle Aged Osteoarthritis, Knee / diagnostic imaging Propensity Score Retrospective Studies

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
11 2019
Historique:
pubmed: 11 9 2019
medline: 7 3 2020
entrez: 11 9 2019
Statut: ppublish

Résumé

Background The exact contribution of statins to knee osteoarthritis (OA) radiographic outcomes and the characteristics of patients with OA as potential responders to statins remain unclear. Purpose To evaluate the effect of statin use on the incidence of radiographic knee OA (development of Kellgren-Lawrence grade ≥2) and progression of joint space narrowing (JSN) according to the nodal OA status defined according to the presence of Heberden nodes (HNs). Materials and Methods Institutional review boards approved this HIPAA-compliant protocol, and all participants gave informed consent. The Osteoarthritis Initiative (OAI) cohort, which began in 2004 and is ongoing (

Identifiants

DOI: 10.1148/radiol.2019190557 PMID: 31502936
pubmed: 31502936
doi: 10.1148/radiol.2019190557
doi:

Substances chimiques

Hydroxymethylglutaryl-CoA Reductase Inhibitors 0

Banques de données

ClinicalTrials.gov
['NCT00080171']

Types de publication

Clinical Trial Journal Article Multicenter Study Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

396-404

Auteurs

Arya Haj-Mirzaian (A)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).
ORCID: 0000-0002-0724-2649

Bahram Mohajer (B)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).
ORCID: 0000-0001-6398-8448

Ali Guermazi (A)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).

Philip G Conaghan (PG)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).
ORCID: 0000-0002-3478-5665

Joao A C Lima (JAC)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).
ORCID: 0000-0001-8756-6995

Michael J Blaha (MJ)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).

Clifton O Bingham (CO)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).

Frank W Roemer (FW)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).
ORCID: 0000-0001-9238-7350

Xu Cao (X)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).

Shadpour Demehri (S)

From the Department of Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science (A.H., S.D.), and Department of Orthopedic Surgery (X.C.), Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran (B.M.); Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England (P.G.C.); NIHR Leeds Biomedical Research Centre, Leeds, England (P.G.C.); Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, Baltimore, Md (J.A.C.L.); Ciccarone Center for the Prevention of Heart Disease (M.J.B.) and Department of Rheumatology (C.O.B.), Johns Hopkins University, Baltimore, Md; and Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.).
ORCID: 0000-0001-5991-5924

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Hyperostose › Exostoses › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Gonarthrose › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Score de propension › Statin Use and Knee Osteoarthritis Outcome...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Statin Use and Knee Osteoarthritis Outcome...