A single nucleotide polymorphism (-250 A/C) of the GFAP gene is associated with brain structures and cerebral blood flow.
astrocytes
cerebral blood flow
diffusion tensor imaging
polymorphism
voxel-based morphometry
Journal
Psychiatry and clinical neurosciences
ISSN: 1440-1819
Titre abrégé: Psychiatry Clin Neurosci
Pays: Australia
ID NLM: 9513551
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
11
01
2019
revised:
13
08
2019
accepted:
07
09
2019
pubmed:
11
9
2019
medline:
24
11
2020
entrez:
11
9
2019
Statut:
ppublish
Résumé
Glial fibrillary acidic protein (GFAP), the intermediate filament protein expressed in astrocytes, plays a key role in many aspects of brain function through communication with neurons or blood vessels. A common single nucleotide polymorphism (SNP), GFAP -250 C/A (rs2070935), is associated with the transcriptional regulation of GFAP, which can potentially result in the genotype-specific brain structure. This study aimed to verify the biological effects of the GFAP variants on brain structure and function. We investigated the associations between the GFAP variants and magnetic resonance imaging findings, including gray and white matter volumes, white matter integrity, and resting arterial blood flow, from 1212 healthy Japanese subjects. The GFAP -250 C/A genotype was significantly associated with total gray matter volume, total white matter volume, average mean diffusivity, and mean cerebral blood flow. In voxel-by-voxel analyses, the GFAP genotype showed significant associations with the regional gray and white matter volumes in the inferior frontal lobe and corpus callosum, the regional mean diffusivity in the left posterior region, and the regional cerebral blood flow throughout the brain. This study revealed a common SNP that is significantly associated with multiple global brain structure parameters.
Substances chimiques
GFAP protein, human
0
Glial Fibrillary Acidic Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-55Subventions
Organisme : A grant from the Strategic Research Program for Brain Sciences from the Japan Agency for Medical Research and Development (AMED) to conduct integrated research on depression, dementia and development disorders
ID : JP19dm0107099
Organisme : A Grant-in-Aid for Scientific Research in Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
ID : 24116007
Organisme : A grant-in-aid for young scientists (A)
ID : KAKENHI 25700012
Organisme : A grant-in-aid for young scientists (B)
ID : KAKENHI 23700306
Organisme : JST/CREST
Organisme : JST/RISTEX
Informations de copyright
© 2019 The Authors. Psychiatry and Clinical Neurosciences © 2019 Japanese Society of Psychiatry and Neurology.
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