Negative Pressure From an Internal Spiral Tissue Expander Generates New Subcutaneous Adipose Tissue in an In Vivo Animal Model.
Journal
Aesthetic surgery journal
ISSN: 1527-330X
Titre abrégé: Aesthet Surg J
Pays: England
ID NLM: 9707469
Informations de publication
Date de publication:
23 03 2020
23 03 2020
Historique:
pubmed:
11
9
2019
medline:
7
1
2021
entrez:
11
9
2019
Statut:
ppublish
Résumé
Tissue expanders are widely utilized in plastic surgery. Traditional expanders usually are "inflatable balloons," which are planned to grow additional skin and/or to create space to be filled, for example, with an implant. In very recent years, reports suggest that negative pressure created by an external device (ie, Brava) induces both skin expansion and adipogenesis. The authors evaluated and assessed the adipogenetic potential of a novel internal tissue expander in an in vivo animal model. New Zealand female rabbits were enrolled in the study. A prototype spiral inner tissue expander was employed. It consisted of a-dynamic conic expander (DCE) with a valve at the end: when empty, it is flat (Archimedean spiral), whereas when filled with a fluid, it takes a conic shape. Inside the conic spiral, a negative pressure is therefore created. DCE is implanted flat under the latissimus dorsi muscle in experimental animals (rabbit) and then filled to reach the conical shape. Animals were investigated with magnetic resonance imaging, histology, and transmission electronic microscopy at 3, 6, and 12 months. Magnetic resonance imaging revealed a marked increase in newly formed adipose tissue, reaching its highest amount at 12 months after the DCE implantation. Histology confirmed the existence of new adipocytes, whereas transmission electronic microscopy ultrastructure confirmed that most of these new cells were mature adipocytes. Tensile stress, associated with negative-pressure expanders, generated newly white subcutaneous adipose tissue.
Sections du résumé
BACKGROUND
Tissue expanders are widely utilized in plastic surgery. Traditional expanders usually are "inflatable balloons," which are planned to grow additional skin and/or to create space to be filled, for example, with an implant. In very recent years, reports suggest that negative pressure created by an external device (ie, Brava) induces both skin expansion and adipogenesis.
OBJECTIVES
The authors evaluated and assessed the adipogenetic potential of a novel internal tissue expander in an in vivo animal model.
METHODS
New Zealand female rabbits were enrolled in the study. A prototype spiral inner tissue expander was employed. It consisted of a-dynamic conic expander (DCE) with a valve at the end: when empty, it is flat (Archimedean spiral), whereas when filled with a fluid, it takes a conic shape. Inside the conic spiral, a negative pressure is therefore created. DCE is implanted flat under the latissimus dorsi muscle in experimental animals (rabbit) and then filled to reach the conical shape. Animals were investigated with magnetic resonance imaging, histology, and transmission electronic microscopy at 3, 6, and 12 months.
RESULTS
Magnetic resonance imaging revealed a marked increase in newly formed adipose tissue, reaching its highest amount at 12 months after the DCE implantation. Histology confirmed the existence of new adipocytes, whereas transmission electronic microscopy ultrastructure confirmed that most of these new cells were mature adipocytes.
CONCLUSIONS
Tensile stress, associated with negative-pressure expanders, generated newly white subcutaneous adipose tissue.
Identifiants
pubmed: 31504155
pii: 5554814
doi: 10.1093/asj/sjz194
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
448-459Informations de copyright
© 2019 The Aesthetic Society. Reprints and permission: journals.permissions@oup.com.