Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials.

Adult Aged Cognition / drug effects Female Humans Isoflavones / pharmacology Male Memory / drug effects Middle Aged Randomized Controlled Trials as Topic Glycine max / chemistry
cognition isoflavones meta-analysis

Journal

Nutrition reviews
ISSN: 1753-4887
Titre abrégé: Nutr Rev
Pays: United States
ID NLM: 0376405

Informations de publication

Date de publication:
01 02 2020
Historique:
pubmed: 11 9 2019
medline: 18 8 2020
entrez: 11 9 2019
Statut: ppublish

Résumé

The results of preclinical and observational studies support the beneficial effect of soy isoflavones on cognition. This review aimed to evaluate the effects of soy isoflavones on cognition in adults. The PUBMED, EMBASE, Ovid Medline, Cochrane Library, and clinicaltrials.gov databases were searched. Two researchers independently screened 1955 records, using the PICOS criteria: participants were adults; intervention was dietary sources with soy isoflavones or isolated soy isoflavones; comparator was any comparator; outcome was cognitive function; study type was randomized controlled trials (RCTs). A third researcher was consulted to resolve any discrepancies. Sixteen RCTs were included and their quality assessed. Information on study design, characteristics of participants, and outcomes was extracted. PRISMA guidelines were followed. A random-effects meta-analysis was used to pool estimates across studies. In the 16 RCTs (1386 participants, mean age = 60 y), soy isoflavones were found to improve overall cognitive function (standardized mean difference [SMD], 0.19; 95% confidence interval [CI], 0.07-0.32) and memory (SMD, 0.15; 95%CI, 0.03-0.26). The results showed that soy isoflavones may improve cognitive function in adults. PROSPERO registration no. CRD42018082070.

Identifiants

DOI: 10.1093/nutrit/nuz050 PMID: 31504836 PMC: PMC7808187
pubmed: 31504836
pii: 5559996
doi: 10.1093/nutrit/nuz050
pmc: PMC7808187
doi:

Substances chimiques

Isoflavones 0

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

134-144

Subventions

Organisme : NIA NIH HHS
ID : RF1 AG051615
Pays : United States

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Références

Menopause. 2007 May-Jun;14(3 Pt 1):489-99
pubmed: 17308499
J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1318-25
pubmed: 23670794
Dement Geriatr Cogn Disord. 2008;26(1):50-7
pubmed: 18583909
Alzheimers Dement. 2015 Sep;11(9):1015-22
pubmed: 26086182
Cytokine. 2018 Apr;104:151-159
pubmed: 29102164
J Nutr Health Aging. 2007 Mar-Apr;11(2):155-64
pubmed: 17435957
J Alzheimers Dis. 2017;59(1):291-300
pubmed: 28598847
JAMA Intern Med. 2015 Jul;175(7):1094-1103
pubmed: 25961184
J Urol. 2009 Nov;182(5):2265-72
pubmed: 19758646
J Nutr. 1999 Mar;129(3):758S-767S
pubmed: 10082786
Brain Res. 2011 Mar 16;1379:206-12
pubmed: 21035431
Food Chem Toxicol. 2014 Mar;65:120-8
pubmed: 24373829
Geriatr Gerontol Int. 2017 Nov;17(11):2103-2108
pubmed: 28345266
Pharmacol Biochem Behav. 2003 Jun;75(3):721-9
pubmed: 12895690
Menopause. 2005 Mar;12(2):193-201
pubmed: 15772567
J Alzheimers Dis. 2015;43(2):669-75
pubmed: 25114086
Neurology. 2016 Aug 16;87(7):699-708
pubmed: 27421538
Curr Cardiol Rev. 2019;15(2):114-135
pubmed: 30516108
Brain Res. 2013 Jun 13;1514:123-7
pubmed: 23415935
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Maturitas. 2011 Mar;68(3):256-63
pubmed: 21237589
J Cardiovasc Med (Hagerstown). 2012 Nov;13(11):735-40
pubmed: 22929565
Medicine (Baltimore). 2015 Dec;94(50):e2281
pubmed: 26683956
Nutr Cancer. 2008;60(1):49-54
pubmed: 18444135
J Alzheimers Dis. 2016;51(3):701-11
pubmed: 26890773
J Alzheimers Dis. 2015;47(4):1009-19
pubmed: 26401779
Eur J Clin Nutr. 2018 Oct;72(10):1458-1462
pubmed: 29348624
Control Clin Trials. 1996 Feb;17(1):1-12
pubmed: 8721797
Clin Endocrinol (Oxf). 2013 Mar;78(3):365-72
pubmed: 22469418
Age Ageing. 2009 Jan;38(1):86-93
pubmed: 19054783
Neurology. 2012 Jun 5;78(23):1841-8
pubmed: 22665144
Menopause. 2014 Oct;21(10):1038-62
pubmed: 25225714
J Nutr. 2002 Dec;132(12):3577-84
pubmed: 12468591
Cancer. 2017 Jun 1;123(11):2070-2079
pubmed: 28263368
Clin Interv Aging. 2018 Oct 26;13:2161-2167
pubmed: 30464425
Neurology. 2018 Apr 3;90(14):e1248-e1256
pubmed: 29549223
Behav Res Methods. 2015 Dec;47(4):1274-1294
pubmed: 25361866
Bioorg Med Chem. 2004 Mar 15;12(6):1559-67
pubmed: 15018930
Biol Pharm Bull. 2001 Apr;24(4):351-6
pubmed: 11305594
J Am Med Dir Assoc. 2017 May 1;18(5):427-432
pubmed: 28108204
Bone. 2010 Aug;47(2):413-23
pubmed: 20452475
BJU Int. 2014 May;113(5b):E119-30
pubmed: 24053483
Proc Soc Exp Biol Med. 1995 Jan;208(1):40-3
pubmed: 7892293
Menopause. 2003 Jul-Aug;10(4):352-61
pubmed: 12851519
J Nutr. 2010 Dec;140(12):2326S-2334S
pubmed: 20980638
J Psychopharmacol. 2015 Jul;29(7):753-63
pubmed: 26040902
Neural Regen Res. 2017 Sep;12(9):1479-1484
pubmed: 29089994
J Steroid Biochem Mol Biol. 2016 Jun;160:67-77
pubmed: 26535810
Menopause. 2009 Nov-Dec;16(6):1167-77
pubmed: 19590458
J Nutr. 2010 Jul;140(7):1363S-8S
pubmed: 20519411
Braz J Med Biol Res. 2010 Nov;43(11):1123-6
pubmed: 20945036
Menopause. 2013 Sep;20(9):936-45
pubmed: 23511704
J Alzheimers Dis. 2018;64(s1):S229-S254
pubmed: 29865058
JAMA. 2004 Jul 7;292(1):65-74
pubmed: 15238592
Ann N Y Acad Sci. 2017 Sep;1403(1):150-163
pubmed: 28945939
J Nutr. 2000 Jul;130(7):1695-9
pubmed: 10867038
J Endocrinol Invest. 2009 Feb;32(2):150-5
pubmed: 19411814
Menopause. 2006 Jul-Aug;13(4):621-30
pubmed: 16837884
Fertil Steril. 2006 Apr;85(4):972-8
pubmed: 16580383
Menopause. 2003 May-Jun;10(3):196-202
pubmed: 12792289
Nutr Cancer. 2007;57(1):1-10
pubmed: 17516857
Menopause. 2015 Feb;22(2):198-206
pubmed: 25003621
J Am Coll Nutr. 2000 Apr;19(2):242-55
pubmed: 10763906
Anticancer Agents Med Chem. 2013 Oct;13(8):1178-87
pubmed: 23919747
Psychopharmacology (Berl). 2001 Oct;157(4):430-6
pubmed: 11605103
Neurology. 2014 Oct 14;83(16):1410-6
pubmed: 25230996
Biomed Pharmacother. 2015 Dec;76:30-8
pubmed: 26653547
Am J Clin Nutr. 2013 May;97(5):1076-82
pubmed: 23553168
J Nutr Health Aging. 2018;22(2):222-229
pubmed: 29380849
Forum Health Econ Policy. 2014 Nov;18(1):25-39
pubmed: 27134606
Am J Geriatr Psychiatry. 2018 Mar;26(3):266-277
pubmed: 29246725
Nutr J. 2017 Sep 11;16(1):56
pubmed: 28893250
Am J Cardiol. 2016 Apr 15;117(8):1355-60
pubmed: 26949037
Neural Regen Res. 2016 Jul;11(7):1153-8
pubmed: 27630702
Rev Recent Clin Trials. 2009 May;4(2):79-88
pubmed: 19463104
Br J Nutr. 2009 Nov;102(9):1348-54
pubmed: 19480732
J Alzheimers Dis. 2017;59(3):815-849
pubmed: 28697569

Auteurs

Chendi Cui (C)

C. Cui, L. Kuller, and A. Sekikawa are with the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Rahel L Birru (RL)

R. Birru is with the Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Beth E Snitz (BE)

B. Snitz and O. Lopez are with the Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Masafumi Ihara (M)

M. Ihara, A. Higashiyama, C. Kakuta, and Y. Miyamoto are with the National Cerebral and Cardiovascular Center, Osaka, Japan.

Chikage Kakuta (C)

M. Ihara, A. Higashiyama, C. Kakuta, and Y. Miyamoto are with the National Cerebral and Cardiovascular Center, Osaka, Japan.

Brian J Lopresti (BJ)

B. Lopresti and C. Mathis are with the Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Howard J Aizenstein (HJ)

H. Aizenstein is with the Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Oscar L Lopez (OL)

B. Snitz and O. Lopez are with the Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Chester A Mathis (CA)

B. Lopresti and C. Mathis are with the Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Yoshihiro Miyamoto (Y)

M. Ihara, A. Higashiyama, C. Kakuta, and Y. Miyamoto are with the National Cerebral and Cardiovascular Center, Osaka, Japan.

Lewis H Kuller (LH)

C. Cui, L. Kuller, and A. Sekikawa are with the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Akira Sekikawa (A)

C. Cui, L. Kuller, and A. Sekikawa are with the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Effects of soy isoflavones on cognitive...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Effects of soy isoflavones on cognitive...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Effects of soy isoflavones on cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects of soy isoflavones on cognitive...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Isoflavones › Effects of soy isoflavones on cognitive...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Effects of soy isoflavones on cognitive...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Effects of soy isoflavones on cognitive...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Effects of soy isoflavones on cognitive...