Vitamin D and ω-3 Supplementations in Mediterranean Diet During the 1st Year of Overt Type 1 Diabetes: A Cohort Study.
Arachidonic Acid
/ administration & dosage
Child
Cholecalciferol
/ administration & dosage
Diabetes Mellitus, Type 1
/ blood
Diet, Mediterranean
Dietary Supplements
Fatty Acids, Omega-3
/ administration & dosage
Female
Glycated Hemoglobin
/ analysis
Humans
Insulin
/ therapeutic use
Insulin Secretion
/ drug effects
Male
Randomized Controlled Trials as Topic
Retrospective Studies
Vitamin D
/ administration & dosage
AA/EPA ratio
DHA
EPA
arachidonic acid
cholecalciferol
honeymoon period
omega3
remission period
type 1 diabetes
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
09 Sep 2019
09 Sep 2019
Historique:
received:
30
06
2019
revised:
10
08
2019
accepted:
27
08
2019
entrez:
12
9
2019
pubmed:
12
9
2019
medline:
4
3
2020
Statut:
epublish
Résumé
Vitamin D and omega 3 fatty acid (ω-3) co-supplementation potentially improves type 1 diabetes (T1D) by attenuating autoimmunity and counteracting inflammation. This cohort study, preliminary to a randomized control trial (RCT), is aimed at evaluating, in a series of T1D children assuming Mediterranean diet and an intake of cholecalciferol of 1000U/day from T1D onset, if ω-3 co-supplementation preserves the residual endogen insulin secretion (REIS). Therefore, the cohort of 22 "new onsets" of 2017 received ω-3 (eicosapentenoic acid (EPA) plus docosahexaenoic acid (DHA), 60 mg/kg/day), and were compared retrospectively vs. the 37 "previous onsets" without ω-3 supplementation. Glicosilated hemoglobin (HbA1c%), the daily insulin demand (IU/Kg/day) and IDAA1c, a composite index (calculated as IU/Kg/day × 4 + HbA1c%), as surrogates of REIS, were evaluated at recruitment (T0) and 12 months later (T12). In the ω-3 supplemented group, dietary intakes were evaluated at T0 and T12. As an outcome, a decreased insulin demand (
Identifiants
pubmed: 31505819
pii: nu11092158
doi: 10.3390/nu11092158
pmc: PMC6770446
pii:
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Glycated Hemoglobin A
0
Insulin
0
hemoglobin A1c protein, human
0
Vitamin D
1406-16-2
Cholecalciferol
1C6V77QF41
Arachidonic Acid
27YG812J1I
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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