Urinary ketone body loss leads to degeneration of brain white matter in elderly SLC5A8-deficient mice.

3-Hydroxybutyric Acid / urine Aging / metabolism Animals Glucose / metabolism Ketone Bodies / urine Kidney / metabolism Leukoencephalopathies / metabolism Male Mice, Inbred C57BL Mice, Mutant Strains Monocarboxylic Acid Transporters / deficiency Tomography, Emission-Computed, Single-Photon White Matter / diagnostic imaging
SLC5A8 brain ketone body kidney white matter

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
08 2020
Historique:
pubmed: 12 9 2019
medline: 2 3 2021
entrez: 12 9 2019
Statut: ppublish

Résumé

SLC5A8 is a sodium-coupled monocarboxylate and ketone transporter expressed in various epithelial cells. A putative role of SLC5A8 in neuroenergetics has been also hypothesized. To clarify this issue, we studied the cerebral phenotype of SLC5A8-deficient mice during aging. Elderly SLC5A8-deficient mice presented diffuse leukoencephalopathy characterized by intramyelinic oedema without demyelination suggesting chronic energetic crisis. Hypo-metabolism in the white matter of elderly SLC5A8-deficient mice was found using

Identifiants

DOI: 10.1177/0271678X19873662 PMID: 31506013 PMC: PMC7370371
pubmed: 31506013
doi: 10.1177/0271678X19873662
pmc: PMC7370371
doi:

Substances chimiques

Ketone Bodies 0
Monocarboxylic Acid Transporters 0
Slc5a8 protein, mouse 0
Glucose IY9XDZ35W2
3-Hydroxybutyric Acid TZP1275679

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1709-1723

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Auteurs

Laurent Suissa (L)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.
Intensive Care Stroke Unit, University Hospital, Nice, France.
ORCID: 0000-0003-2345-8711

Virginie Flachon (V)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.

Jean-Marie Guigonis (JM)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.

Charles-Vivien Olivieri (CV)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.
ORCID: 0000-0002-5237-7358

Fanny Burel-Vandenbos (F)

Department of Pathology, University Hospital, Nice, France.

Julien Guglielmi (J)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.

Damien Ambrosetti (D)

Matthieu Gérard (M)

Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University of Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.

Philippe Franken (P)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.
Nuclear Medicine Department, Center Antoine Lacassagne, Nice, France.

Jacques Darcourt (J)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.
Nuclear Medicine Department, Center Antoine Lacassagne, Nice, France.

Luc Pellerin (L)

Département de Physiologie, Université de Lausanne, Lausanne, Switzerland.
Centre de Résonance Magnétique des Systèmes Biologiques, UMR5536 CNRS, Université de Bordeaux, Bordeaux, France.

Thierry Pourcher (T)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.
ORCID: 0000-0003-2839-4622

Sabine Lindenthal (S)

Laboratory Transporter in Imaging and Radiotherapy in Oncology (TIRO), University Nice Sophia Antipolis, Institut de biosciences et biotechnologies d'Aix-Marseille (BIAM), Commissariat a l'Energie Atomique, University Côte d'Azur, Nice, France.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Butyrates › Hydroxy-butyrates › Acide 3-hydroxy-butyrique › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Eucaryotes › Animaux › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Corps cétoniques › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Leucoencéphalopathies › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'acides monocarboxyliques › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › Urinary ketone body loss leads to degeneration...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Urinary ketone body loss leads to degeneration...