The roles of glucagon-like peptide-2 and the intestinal epithelial insulin-like growth factor-1 receptor in regulating microvillus length.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
received:
20
05
2019
accepted:
27
08
2019
entrez:
12
9
2019
pubmed:
12
9
2019
medline:
5
11
2020
Statut:
epublish
Résumé
Microvilli are tiny projections on the apical end of enterocytes, aiding in the digestion and absorption of nutrients. One of their key features is uniform length, but how this is regulated is poorly understood. Glucagon-like peptide-2 (GLP-2) has been shown to increase microvillus length but, the requirement of its downstream mediator, the intestinal epithelial insulin-like growth factor-1 receptor (IE-IGF-1R), and the microvillus proteins acted upon by GLP-2, remain unknown. Using IE-IGF-1R knockout (KO) mice, treated with either long-acting human (h) (GLY
Identifiants
pubmed: 31506583
doi: 10.1038/s41598-019-49510-5
pii: 10.1038/s41598-019-49510-5
pmc: PMC6737075
doi:
Substances chimiques
Glucagon-Like Peptide 2
0
IRTKS protein, mouse
0
Igf1r protein, mouse
0
Microfilament Proteins
0
Receptor, IGF Type 1
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13010Subventions
Organisme : CIHR
ID : PJT-14853
Pays : Canada
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