βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Animals
Cell Line, Tumor
Cell Survival
/ radiation effects
DNA Damage
DNA Repair
/ radiation effects
DNA-Binding Proteins
/ metabolism
HEK293 Cells
Humans
Intestines
/ pathology
Mice, Inbred C57BL
Protein Binding
/ radiation effects
Protein Processing, Post-Translational
/ radiation effects
Radiation Tolerance
/ radiation effects
Radiation, Ionizing
Tumor Suppressor p53-Binding Protein 1
/ metabolism
Ubiquitin-Protein Ligases
/ metabolism
beta-Arrestin 1
/ metabolism
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
05
10
2018
accepted:
08
08
2019
revised:
06
08
2019
pubmed:
12
9
2019
medline:
30
6
2021
entrez:
12
9
2019
Statut:
ppublish
Résumé
Cellular DNA is constantly under threat from internal and external insults, consequently multiple pathways have evolved to maintain chromosomal fidelity. Our previous studies revealed that chronic stress, mediated by continuous stimulation of the β
Identifiants
pubmed: 31506606
doi: 10.1038/s41418-019-0406-6
pii: 10.1038/s41418-019-0406-6
pmc: PMC7206116
doi:
Substances chimiques
DNA-Binding Proteins
0
RAD18 protein, human
0
TP53BP1 protein, human
0
Trp53bp1 protein, mouse
0
Tumor Suppressor p53-Binding Protein 1
0
beta-Arrestin 1
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1200-1213Références
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