Exogenous hormone use and cutaneous melanoma risk in women: The European Prospective Investigation into Cancer and Nutrition.
Adult
Aged
Confounding Factors, Epidemiologic
Contraceptives, Oral, Hormonal
/ adverse effects
Estrogen Replacement Therapy
/ adverse effects
Europe
/ epidemiology
Female
Humans
Incidence
Melanoma
/ epidemiology
Middle Aged
Postmenopause
Premenopause
Proportional Hazards Models
Prospective Studies
Risk Factors
Skin Neoplasms
/ epidemiology
Surveys and Questionnaires
/ statistics & numerical data
Time Factors
cohort studies
cutaneous melanoma
epidemiology
hormonal treatments
menopausal hormone therapy
oral contraceptives
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
21
05
2019
revised:
12
07
2019
accepted:
25
07
2019
pubmed:
12
9
2019
medline:
9
3
2021
entrez:
12
9
2019
Statut:
ppublish
Résumé
Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Information on exogenous hormone use at baseline was derived from country-specific self-administered questionnaires. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Over 1992-2015, 1,696 melanoma cases were identified among 334,483 women, whereof 770 cases among 134,758 postmenopausal women. There was a positive, borderline-significant association between OC use and melanoma risk (HR = 1.12, 95% CI = 1.00-1.26), with no detected heterogeneity across countries (p
Substances chimiques
Contraceptives, Oral, Hormonal
0
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3267-3280Subventions
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Informations de copyright
© 2019 UICC.
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