Social and non-social autism symptoms and trait domains are genetically dissociable.
Autism spectrum disorders
Genetic predisposition to disease
Genome-wide association studies
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
12
2018
accepted:
19
07
2019
entrez:
12
9
2019
pubmed:
12
9
2019
medline:
12
9
2019
Statut:
epublish
Résumé
The core diagnostic criteria for autism comprise two symptom domains - social and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to suggest that these two domains are dissociable, though this hypothesis has not yet been tested using molecular genetics. We test this using a genome-wide association study (
Identifiants
pubmed: 31508503
doi: 10.1038/s42003-019-0558-4
pii: 558
pmc: PMC6722082
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
328Subventions
Organisme : NIMH NIH HHS
ID : R00 MH113823
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215/2/13/2
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing interestsD.A.H. and the 23andMe Research Team are employees of 23andMe, Inc. The remaining authors declare no competing interests.
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