Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT.
Embryo transfer
Endometrium
Randomized controlled trial.
Platelet-rich plasma
Journal
International journal of reproductive biomedicine
ISSN: 2476-4108
Titre abrégé: Int J Reprod Biomed
Pays: Iran
ID NLM: 101679102
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
11
06
2018
revised:
25
12
2018
accepted:
30
01
2019
entrez:
12
9
2019
pubmed:
12
9
2019
medline:
12
9
2019
Statut:
epublish
Résumé
Adequate endometrial growth is principal for implantation and pregnancy. Thin endometrium is associated with lower pregnancy rate in assisted reproductive technology. Some frozen-thawed embryo transfer cycles are cancelled due to inadequate endometrial growth. To assess the effectiveness of autologous platelet-rich plasma (PRP) intrauterine infusion for the treatment of thin endometrium. A total of 72 patients who had a history of cancelled frozen-thawed embryo transfer cycle due to the thin endometrium ( Endometrial thickness increased at 48 hr after the first intervention in both groups. All participants needed second intervention due to an inadequate endometrial expansion. After second intervention, endometrial thickness was 7.21 According to this trial, PRP was effective in endometrial expansion in patients with refractory thin endometrium.
Sections du résumé
BACKGROUND
BACKGROUND
Adequate endometrial growth is principal for implantation and pregnancy. Thin endometrium is associated with lower pregnancy rate in assisted reproductive technology. Some frozen-thawed embryo transfer cycles are cancelled due to inadequate endometrial growth.
OBJECTIVE
OBJECTIVE
To assess the effectiveness of autologous platelet-rich plasma (PRP) intrauterine infusion for the treatment of thin endometrium.
MATERIALS AND METHODS
METHODS
A total of 72 patients who had a history of cancelled frozen-thawed embryo transfer cycle due to the thin endometrium (
RESULTS
RESULTS
Endometrial thickness increased at 48 hr after the first intervention in both groups. All participants needed second intervention due to an inadequate endometrial expansion. After second intervention, endometrial thickness was 7.21
CONCLUSION
CONCLUSIONS
According to this trial, PRP was effective in endometrial expansion in patients with refractory thin endometrium.
Identifiants
pubmed: 31508569
doi: 10.18502/ijrm.v17i6.4816
pmc: PMC6719514
doi:
Types de publication
Journal Article
Langues
eng
Pagination
443-448Déclaration de conflit d'intérêts
No conflict of interests has been declared.
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