Treatment of hepatitis C in two paediatric patients using sofosbuvir during haematopoietic stem cell transplantation.

Antiviral Agents / administration & dosage Child Child, Preschool Dasatinib / administration & dosage Female Hematopoietic Stem Cell Transplantation Hepatitis C / drug therapy Humans RNA, Viral / blood Ribavirin / administration & dosage Sofosbuvir / administration & dosage Viral Load

Journal

Antiviral therapy
ISSN: 2040-2058
Titre abrégé: Antivir Ther
Pays: England
ID NLM: 9815705

Informations de publication

Date de publication:
2019
Historique:
accepted: 17 06 2019
pubmed: 12 9 2019
medline: 27 10 2020
entrez: 12 9 2019
Statut: ppublish

Résumé

We report the first two paediatric cases of sofosbuvir treatment during high-intensity myeloablative conditioning and engraftment phases of haematopoietic stem cell transplantation. These reports highlight the safety of sofosbuvir during all phases of transplantation and the lack of interaction between sofosbuvir and alkylating or immunosuppressive agents.

Identifiants

DOI: 10.3851/IMP3332 PMID: 31509110
pubmed: 31509110
doi: 10.3851/IMP3332
doi:

Substances chimiques

Antiviral Agents 0
RNA, Viral 0
Ribavirin 49717AWG6K
Dasatinib RBZ1571X5H
Sofosbuvir WJ6CA3ZU8B

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

603-607

Auteurs

Antonio G Grasso (AG)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Aurelio Sonzogni (A)

Department of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy.

Davide Zanon (D)

Pharmacy and Clinical Pharmacology Unit, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.

Alessandra Maestro (A)

Pharmacy and Clinical Pharmacology Unit, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.

Stefano Loiacono (S)

Pharmacy and Clinical Pharmacology Unit, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.

Natalia Maximova (N)

Bone Marrow Transplant Unit, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Dasatinib › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Hépatite › Hépatites virales humaines › Hépatite C › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Ribavirine › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine monophosphate › Sofosbuvir › Treatment of hepatitis C in two paediatric...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Treatment of hepatitis C in two paediatric...