The PVN enhances cardiorespiratory responses to acute hypoxia via input to the nTS.
Animals
Gene Expression Regulation
/ drug effects
Green Fluorescent Proteins
/ metabolism
Hypoxia
/ metabolism
Luminescent Proteins
/ metabolism
Male
Neurons
/ drug effects
Oxygen
/ pharmacology
Paraventricular Hypothalamic Nucleus
/ cytology
Piperazines
/ pharmacology
Proto-Oncogene Proteins c-fos
/ genetics
Rats
Rats, Sprague-Dawley
Solitary Nucleus
/ physiology
Red Fluorescent Protein
GiDREADD
chemoreflex
sympathetic nervous system
ventilation
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
pubmed:
12
9
2019
medline:
21
4
2020
entrez:
12
9
2019
Statut:
ppublish
Résumé
Chemoreflex neurocircuitry includes the paraventricular nucleus (PVN), but the role of PVN efferent projections to specific cardiorespiratory nuclei is unclear. We hypothesized that the PVN contributes to cardiorespiratory responses to hypoxia via projections to the nucleus tractus solitarii (nTS). Rats received bilateral PVN microinjections of adeno-associated virus expressing inhibitory designer receptor exclusively activated by designer drug (GiDREADD) or green fluorescent protein (GFP) control. Efficacy of GiDREADD inhibition by the designer receptor exclusively activated by designer drug (DREADD) agonist Compound 21 (C21) was verified in PVN slices; C21 reduced evoked action potential discharge by reducing excitability to injected current in GiDREADD-expressing PVN neurons. We evaluated hypoxic ventilatory responses (plethysmography) and PVN and nTS neuronal activation (cFos immunoreactivity) to 2 h hypoxia (10% O
Identifiants
pubmed: 31509428
doi: 10.1152/ajpregu.00135.2019
pmc: PMC6962628
doi:
Substances chimiques
DREADD agonist compound 21
0
Luminescent Proteins
0
Piperazines
0
Proto-Oncogene Proteins c-fos
0
Green Fluorescent Proteins
147336-22-9
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
R818-R833Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL098602
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL140858
Pays : United States
Références
Exp Neurol. 2016 Nov;285(Pt A):1-11
pubmed: 27569537
Neuroscience. 2010 May 5;167(2):510-27
pubmed: 20153814
Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R789-97
pubmed: 15919733
Exp Physiol. 2007 Jan;92(1):87-97
pubmed: 17138622
J Physiol. 1987 Dec;394:393-414
pubmed: 3443972
Brain Res. 2001 Mar 23;895(1-2):33-40
pubmed: 11259757
Physiol Behav. 1997 Feb;61(2):325-30
pubmed: 9035265
Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1121-8
pubmed: 15001434
Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R653-5
pubmed: 16105820
Hypertension. 2018 Oct;72(4):994-1001
pubmed: 30354709
Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1219-32
pubmed: 22403798
Am J Physiol. 1989 Jun;256(6 Pt 2):R1325-30
pubmed: 2567578
Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R721-31
pubmed: 26157062
Neuron. 2014 May 21;82(4):723-5
pubmed: 24853931
Clin Exp Hypertens. 1995 Jan-Feb;17(1-2):167-79
pubmed: 7735267
J Appl Physiol (1985). 2007 Jan;102(1):189-99
pubmed: 16857863
Am J Physiol. 1999 Jun;276(6):H1902-10
pubmed: 10362669
Am J Physiol Regul Integr Comp Physiol. 2013 Nov 15;305(10):R1112-23
pubmed: 24049118
J Neurosci. 1995 Dec;15(12):7979-88
pubmed: 8613735
Neuroscience. 2011 Sep 8;190:207-27
pubmed: 21704133
ACS Pharmacol Transl Sci. 2018 Sep 14;1(1):61-72
pubmed: 30868140
Neuroscience. 2008 May 15;153(3):605-17
pubmed: 18424005
Am J Physiol. 1999 Aug;277(2):R403-11
pubmed: 10444546
Am J Physiol. 1996 Jun;270(6 Pt 2):R1273-8
pubmed: 8764294
Brain Res. 1994 Oct 31;662(1-2):127-33
pubmed: 7859065
Am J Physiol Regul Integr Comp Physiol. 2001 Nov;281(5):R1411-9
pubmed: 11641110
J Physiol. 2009 Jan 15;587(2):461-75
pubmed: 19047207
Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1167-R1182
pubmed: 30230933
Brain Res. 1998 Aug 10;801(1-2):239-43
pubmed: 9729407
J Neurophysiol. 2010 Apr;103(4):2095-106
pubmed: 20164386
Neuroscience. 2008 Nov 19;157(2):463-72
pubmed: 18838112
Brain Res. 2003 Dec 12;993(1-2):30-41
pubmed: 14642828
J Physiol. 1994 Jul 1;478 ( Pt 1):55-66
pubmed: 7965835
Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1549-57
pubmed: 27016581
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8
pubmed: 17360345
Nat Rev Neurosci. 2006 May;7(5):335-46
pubmed: 16760914
J Auton Nerv Syst. 1987 Nov;21(1):83-6
pubmed: 3440820
Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R982-R995
pubmed: 28404583
Drug Discov Today. 2014 Apr;19(4):469-73
pubmed: 24184433
J Neurophysiol. 2019 Feb 1;121(2):602-608
pubmed: 30565964
Neuroendocrinology. 1983;36(3):165-86
pubmed: 6601247
J Comp Neurol. 1982 Mar 1;205(3):260-72
pubmed: 6122696
Anesth Analg. 1996 Aug;83(2):329-35
pubmed: 8694314
Psychoneuroendocrinology. 2011 Oct;36(9):1312-26
pubmed: 21481539
J Comp Neurol. 2010 May 1;518(9):1460-99
pubmed: 20187136
Cell Tissue Res. 1978 Jan 31;186(3):423-33
pubmed: 342106
J Appl Physiol (1985). 2018 May 1;124(5):1233-1243
pubmed: 29357503
J Neurosci. 2008 Nov 5;28(45):11731-40
pubmed: 18987209
Brain Res. 2001 Mar 23;895(1-2):167-72
pubmed: 11259774
eNeuro. 2016 Nov 1;3(5):
pubmed: 27822508
Annu Rev Physiol. 1994;56:93-116
pubmed: 7912060
Neuron. 2014 May 21;82(4):797-808
pubmed: 24768300
J Neurosci. 2018 Sep 12;38(37):7969-7975
pubmed: 30082415
J Neurosci. 2002 Apr 15;22(8):3215-26
pubmed: 11943822
Neurosci Lett. 1997 Aug 29;232(2):63-6
pubmed: 9302087
J Neurophysiol. 2016 Mar;115(3):1691-702
pubmed: 26719090