Diet-Induced Obese Mice and Leptin-Deficient
Animals
Diet, High-Fat
/ adverse effects
Gastric Inhibitory Polypeptide
/ blood
Gene Expression
Interleukin 1 Receptor Antagonist Protein
/ blood
Leptin
/ deficiency
Male
Mice, Inbred C57BL
Mice, Obese
Obesity
/ etiology
Receptors, G-Protein-Coupled
/ genetics
Receptors, Gastrointestinal Hormone
/ genetics
Lepob/ob
diet-induced obese (DIO) mice
glucose-dependent insulinotropic polypeptide (GIP)
high-fat diet
interleukin-1 receptor antagonist (IL-1Ra)
leptin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Sep 2019
10 Sep 2019
Historique:
received:
26
07
2019
revised:
06
09
2019
accepted:
07
09
2019
entrez:
13
9
2019
pubmed:
13
9
2019
medline:
11
2
2020
Statut:
epublish
Résumé
As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However, the mechanism of GIP hypersecretion remains largely unknown. In the present study, we investigated GIP secretion in two mouse models of obesity: High-fat diet-induced obese (DIO) mice and leptin-deficient
Identifiants
pubmed: 31509948
pii: ijms20184448
doi: 10.3390/ijms20184448
pmc: PMC6769670
pii:
doi:
Substances chimiques
Interleukin 1 Receptor Antagonist Protein
0
Leptin
0
Receptors, G-Protein-Coupled
0
Receptors, Gastrointestinal Hormone
0
Gastric Inhibitory Polypeptide
59392-49-3
gastric inhibitory polypeptide receptor
D6H00MV7K8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_UU_12012/3
Pays : United Kingdom
Organisme : Japan Society for the Promotion of Science
ID : 19K07281
Organisme : Medical Research Council
ID : MC_UU_12012/2
Pays : United Kingdom
Organisme : Japan Society for the Promotion of Science
ID : 17KK0188
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600717
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/3
Pays : United Kingdom
Organisme : Japan Society for the Promotion of Science
ID : 19K06757
Organisme : Medical Research Council
ID : G0802051
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400192
Pays : United Kingdom
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