Differential Expression Profiles of Oxidative Stress Levels, 8-oxo-dG and 4-HNE, in Barrett's Esophagus Compared to Esophageal Adenocarcinoma.
8-Hydroxy-2'-Deoxyguanosine
/ metabolism
Adenocarcinoma
/ diagnosis
Adult
Aged
Aged, 80 and over
Aldehydes
/ metabolism
Apoptosis
/ genetics
Barrett Esophagus
/ diagnosis
Cell Proliferation
/ genetics
Esophageal Neoplasms
/ diagnosis
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Oxidative Stress
Transcriptome
4-HNE
8-oxo-dG
Barrett’s esophagus
esophageal adenocarcinoma
mitochondrial instability
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Sep 2019
10 Sep 2019
Historique:
received:
20
08
2019
accepted:
03
09
2019
entrez:
13
9
2019
pubmed:
13
9
2019
medline:
11
2
2020
Statut:
epublish
Résumé
Barrett's esophagus (BE), a chronic inflammatory condition, is the leading risk factor for esophageal adenocarcinoma (EAC). In inflammation to cancer pathways, oxidative stress profiles have been linked to cancer progression. However, the relevance of oxidative stress profiles along the BE-disease sequence remains to be elucidated. In this study, markers of oxidative stress; DNA adducts (8-oxo-dG) and lipoperoxidation (4-HNE), and markers of proliferation (Ki67) were measured in patient biopsies representing the BE-disease sequence. Differences in expression of these markers in Barrett's patients with cancer-progression and non-progression were examined. Proliferation was reduced in Barrett's specialized intestinal metaplasia (SIM) compared with EAC (
Identifiants
pubmed: 31509954
pii: ijms20184449
doi: 10.3390/ijms20184449
pmc: PMC6770156
pii:
doi:
Substances chimiques
Aldehydes
0
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
4-hydroxy-2-nonenal
K1CVM13F96
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Irish Cancer Society
ID : CRS11OFA
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