Potential of Curcumin in Skin Disorders.
antioxidants
atopic dermatitis
curcumin
iatrogenic dermatitis
inflammaging
inflammatory skin diseases
molecular docking
psoriasis
skin aging
skin cancer
skin infections
wound care
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
received:
11
07
2019
revised:
05
08
2019
accepted:
15
08
2019
entrez:
13
9
2019
pubmed:
13
9
2019
medline:
26
2
2020
Statut:
epublish
Résumé
Curcumin is a compound isolated from turmeric, a plant known for its medicinal use. Recently, there is a growing interest in the medical community in identifying novel, low-cost, safe molecules that may be used in the treatment of inflammatory and neoplastic diseases. An increasing amount of evidence suggests that curcumin may represent an effective agent in the treatment of several skin conditions. We examined the most relevant in vitro and in vivo studies published to date regarding the use of curcumin in inflammatory, neoplastic, and infectious skin diseases, providing information on its bioavailability and safety profile. Moreover, we performed a computational analysis about curcumin's interaction towards the major enzymatic targets identified in the literature. Our results suggest that curcumin may represent a low-cost, well-tolerated, effective agent in the treatment of skin diseases. However, bypass of limitations of its in vivo use (low oral bioavailability, metabolism) is essential in order to conduct larger clinical trials that could confirm these observations. The possible use of curcumin in combination with traditional drugs and the formulations of novel delivery systems represent a very promising field for future applicative research.
Identifiants
pubmed: 31509968
pii: nu11092169
doi: 10.3390/nu11092169
pmc: PMC6770633
pii:
doi:
Substances chimiques
Dermatologic Agents
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Clin Toxicol (Phila). 2018 May;56(5):384-385
pubmed: 28994311
Nat Prod Rep. 2011 Nov;28(12):1937-55
pubmed: 21979811
Br J Nutr. 2012 Oct;108(7):1272-9
pubmed: 22099425
Biochem Pharmacol. 2010 Oct 1;80(7):1021-32
pubmed: 20599780
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20
pubmed: 21467222
Int J Mol Med. 2017 May;39(5):1307-1316
pubmed: 28339005
Radiat Res. 2013 Jul;180(1):34-43
pubmed: 23745991
PLoS One. 2013 Jun 25;8(6):e67078
pubmed: 23825622
Br J Pharmacol. 2013 Aug;169(8):1672-92
pubmed: 23425071
Cancer Chemother Pharmacol. 2019 Feb;83(2):265-275
pubmed: 30430227
J Altern Complement Med. 2009 Jun;15(6):669-72
pubmed: 19480603
Int J Mol Sci. 2013 Apr 26;14(5):9126-67
pubmed: 23624605
Clin Dermatol. 2017 Mar - Apr;35(2):163-167
pubmed: 28274353
J Dermatol Sci. 2017 Mar;85(3):152-161
pubmed: 27720464
Eur J Dermatol. 2016 Apr 1;26(2):127-32
pubmed: 26711531
Dev Cell. 2006 Sep;11(3):301-12
pubmed: 16950122
J Biol Chem. 1995 Oct 20;270(42):24995-5000
pubmed: 7559628
Gerontology. 2019;65(5):495-504
pubmed: 31055573
Biomed Res Int. 2015;2015:283634
pubmed: 26090395
Biochem Biophys Res Commun. 2013 Nov 8;441(1):53-8
pubmed: 24134840
J Am Acad Dermatol. 2008 Apr;58(4):625-31
pubmed: 18249471
Int J Mol Sci. 2019 Mar 05;20(5):
pubmed: 30841550
Mol Cancer Ther. 2009 Sep;8(9):2726-35
pubmed: 19723881
Antioxid Redox Signal. 2009 Feb;11(2):241-9
pubmed: 18976114
Genes Nutr. 2011 May;6(2):93-108
pubmed: 21516481
Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141
pubmed: 20066113
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26
pubmed: 26658771
Trends Pharmacol Sci. 2009 Feb;30(2):85-94
pubmed: 19110321
Int J Cancer. 2004 Sep 1;111(3):381-7
pubmed: 15221965
J Int Med Res. 2009 Sep-Oct;37(5):1528-42
pubmed: 19930861
Science. 2009 May 29;324(5931):1190-2
pubmed: 19478181
J Asian Nat Prod Res. 2017 May;19(5):489-503
pubmed: 27690628
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):183-9
pubmed: 17400527
Biomaterials. 2013 Sep;34(27):6377-87
pubmed: 23726229
Contact Dermatitis. 2016 Jul;75(1):52-3
pubmed: 27264290
J Microencapsul. 2019 Mar;36(2):156-168
pubmed: 31030591
Tissue Eng Part B Rev. 2011 Dec;17(6):431-6
pubmed: 21682602
J Nutr. 2015 Aug;145(8):1800-7
pubmed: 26108541
J Agric Food Chem. 2011 Sep 14;59(17):9280-9
pubmed: 21797282
Curr Med Res Opin. 2016 Aug;32(8):1345-9
pubmed: 27046744
J Comput Aided Mol Des. 2010 May;24(5):417-22
pubmed: 20401516
PLoS One. 2013 Nov 08;8(11):e79748
pubmed: 24255713
J Nutr Sci Vitaminol (Tokyo). 2015;61(1):37-44
pubmed: 25994138
Chem Biol Interact. 2010 Jan 27;183(2):304-16
pubmed: 19914224
Drug Dev Ind Pharm. 2019 Mar;45(3):395-404
pubmed: 30442066
J Diet Suppl. 2018 Sep 3;15(5):606-612
pubmed: 29095653
Exp Cell Res. 2001 Dec 10;271(2):305-14
pubmed: 11716543
EMBO Mol Med. 2009 Aug;1(5):260-7
pubmed: 20049729
BMC Complement Altern Med. 2012 Mar 24;12:22
pubmed: 22443687
Cancer Chemother Pharmacol. 2010 Oct;66(5):999-1003
pubmed: 20521051
Biochimie. 2016 Apr;123:73-80
pubmed: 26826458
Nature. 2008 May 15;453(7193):314-21
pubmed: 18480812
Curr Eye Res. 2010 Apr;35(4):352-60
pubmed: 20373902
AAPS J. 2013 Jan;15(1):195-218
pubmed: 23143785
Eur J Med Chem. 2018 Mar 25;148:291-305
pubmed: 29466778
Int J Inflam. 2015;2015:316235
pubmed: 26356299
J Trauma. 2001 Nov;51(5):927-31
pubmed: 11706342
Biotechnol Adv. 2014 Nov 1;32(6):1053-64
pubmed: 24793420
Am Fam Physician. 2008 May 15;77(10):1415-20
pubmed: 18533375
Carcinogenesis. 2004 Nov;25(11):2183-9
pubmed: 15256484
Pharmacol Ther. 2004 Aug;103(2):147-66
pubmed: 15369681
Carcinogenesis. 2006 Aug;27(8):1636-44
pubmed: 16501251
Crit Rev Food Sci Nutr. 2020;60(6):887-939
pubmed: 30632782
Cell Mol Life Sci. 2013 Jun;70(12):2059-81
pubmed: 23052205
J Vet Sci. 2016 Dec 30;17(4):435-444
pubmed: 27030193
Biomaterials. 2004 May;25(10):1911-7
pubmed: 14738855
Exp Dermatol. 2018 Feb;27(2):115-123
pubmed: 29152791
Tumour Biol. 2015 May;36(5):3591-9
pubmed: 25542235
J Allergy Clin Immunol. 2003 Dec;112(6 Suppl):S128-39
pubmed: 14657843
Cancer Res. 2002 Jul 1;62(13):3868-75
pubmed: 12097302
Nutr Cancer. 2018 Feb-Mar;70(2):164-175
pubmed: 29300102
Springerplus. 2016 Oct 6;5(1):1732
pubmed: 27777867
Cancer Res. 1996 Jul 15;56(14):3244-9
pubmed: 8764116
Contact Dermatitis. 2014 Jul;71(1):1-12
pubmed: 24621152
Longev Healthspan. 2013 May 02;2(1):8
pubmed: 24472098
Int Immunopharmacol. 2012 Jan;12(1):151-7
pubmed: 22138522
Adv Exp Med Biol. 2007;595:471-80
pubmed: 17569225
J Biol Chem. 2004 Dec 3;279(49):51163-71
pubmed: 15383533
Phytother Res. 2018 Jun;32(6):985-995
pubmed: 29480523
J Photochem Photobiol B. 2018 Dec;189:21-28
pubmed: 30273795
Biol Reprod. 2016 Aug 31;95(4):83
pubmed: 27580989
Wound Repair Regen. 1999 Sep-Oct;7(5):362-74
pubmed: 10564565
Curr Drug Discov Technol. 2020;17(2):248-260
pubmed: 30332967
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1642-1652
pubmed: 31027431
Clin Cancer Res. 2008 Jul 15;14(14):4491-9
pubmed: 18628464
Biomed Res Int. 2014;2014:747584
pubmed: 24772435
Mol Pharm. 2007 Nov-Dec;4(6):807-18
pubmed: 17999464
Phytomedicine. 2007 Nov;14(11):711-5
pubmed: 17923398
Semin Cutan Med Surg. 2016 Jun;35(2):57-61
pubmed: 27416309
Dermatitis. 2006 Dec;17(4):196-7
pubmed: 17150169
Lasers Med Sci. 2017 Aug;32(6):1337-1342
pubmed: 28646389
J Immunotoxicol. 2015 Apr-Jun;12(2):188-93
pubmed: 24926560
Pharmazie. 2007 Dec;62(12):937-42
pubmed: 18214347
Biochem Biophys Res Commun. 2014 May 23;448(1):15-21
pubmed: 24735534
J Pharm Pharmacol. 2018 Jul;70(7):919-928
pubmed: 29600580
J Cell Physiol. 2019 May;234(5):5728-5740
pubmed: 30317564
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
Biochem Pharmacol. 2010 Feb 1;79(3):330-8
pubmed: 19735646
Free Radic Res. 2014 Nov;48(11):1342-54
pubmed: 25119790
Toxicol Mech Methods. 2015;25(4):340-6
pubmed: 25996037
Int J Biol Macromol. 2016 Dec;93(Pt B):1519-1529
pubmed: 27180291
J Cell Biol. 1989 Aug;109(2):903-14
pubmed: 2760116
Br J Dermatol. 2000 Nov;143(5):937-49
pubmed: 11069500
Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6
pubmed: 17101300
AAPS PharmSciTech. 2013 Dec;14(4):1303-12
pubmed: 23990077
Food Chem Toxicol. 1994 Mar;32(3):279-83
pubmed: 8157223
PLoS One. 2015 Mar 24;10(3):e0120179
pubmed: 25803281
Pharmacol Res. 1999 Jan;39(1):41-7
pubmed: 10051376
Life Sci. 2014 Oct 22;116(1):1-7
pubmed: 25200875
BMJ Case Rep. 2018 Sep 10;2018:
pubmed: 30206065
Int J Nanomedicine. 2019 Jan 11;14:557-571
pubmed: 30666114
J Biomed Nanotechnol. 2011 Jun;7(3):406-14
pubmed: 21830481
Mech Ageing Dev. 2007 Jan;128(1):92-105
pubmed: 17116321
Mol Carcinog. 2007 Aug;46(8):711-5
pubmed: 17538953
Biomed Res Int. 2014;2014:186864
pubmed: 24877064
Appl Biochem Biotechnol. 2013 Sep;171(2):396-402
pubmed: 23842671
Biochemistry. 2016 Mar 1;55(8):1226-38
pubmed: 26859324
BMC Complement Altern Med. 2006 Mar 17;6:10
pubmed: 16545122
Nutr Cancer. 2010;62(8):1137-41
pubmed: 21058202
Biofactors. 2013 Jan-Feb;39(1):2-13
pubmed: 23339055
Adv Exp Med Biol. 2007;595:343-57
pubmed: 17569219
Cancer Chemother Pharmacol. 2018 Oct;82(4):695-706
pubmed: 30074076
Clin Exp Dermatol. 2001 Sep;26(6):525-30
pubmed: 11678882
Biofactors. 2002;16(1-2):29-43
pubmed: 12515914
Drug Res (Stuttg). 2015 Oct;65(10):521-5
pubmed: 25050518
Free Radic Biol Med. 2010 Nov 15;49(9):1328-41
pubmed: 20696237
PLoS One. 2016 Mar 09;11(3):e0150952
pubmed: 26959360
Photochem Photobiol. 2002 Jul;76(1):73-80
pubmed: 12126310
Ann Med. 2008;40(7):482-95
pubmed: 18608118
Cell Res. 2009 Jan;19(1):128-39
pubmed: 19114990
Clin Cancer Res. 2001 Jul;7(7):1894-900
pubmed: 11448902
FASEB J. 2004 May;18(7):816-27
pubmed: 15117886
J Invest Dermatol. 1990 Jun;94(6 Suppl):128S-134S
pubmed: 2161886
Cancer Lett. 2001 Oct 30;172(2):111-8
pubmed: 11566484
Scand J Gastroenterol. 2019 May;54(5):633-639
pubmed: 31131678
Toxicology. 1980;16(3):259-65
pubmed: 7423534
Bioinformation. 2017 Nov 30;13(11):356-359
pubmed: 29225427
J Biomol Struct Dyn. 2019 Mar;37(5):1220-1230
pubmed: 29546799
Dev Biol. 1999 Aug 15;212(2):278-89
pubmed: 10433821
Curr Top Med Chem. 2016;16(6):634-54
pubmed: 26286213
ACS Med Chem Lett. 2014 Nov 20;6(1):37-41
pubmed: 25589927
J Cosmet Dermatol. 2019 Dec;18(6):1866-1874
pubmed: 30809971
Int Immunopharmacol. 2012 Jan;12(1):131-8
pubmed: 22101249
Cancer Metastasis Rev. 2011 Dec;30(3-4):343-61
pubmed: 22038018
Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895
pubmed: 26528921
Hum Pathol. 1996 Nov;27(11):1180-4
pubmed: 8912828
Colloids Surf B Biointerfaces. 2013 Nov 1;111:367-75
pubmed: 23856543
Cancer Biol Ther. 2011 Jan 15;11(2):216-28
pubmed: 21088500
Annu Rev Food Sci Technol. 2015;6:299-327
pubmed: 25705933
J Biomed Nanotechnol. 2016 Apr;12(4):679-88
pubmed: 27301194
Mol Cancer Ther. 2009 Aug;8(8):2348-55
pubmed: 19671757
Nat Rev Mol Cell Biol. 2009 Mar;10(3):207-17
pubmed: 19209183
Science. 1997 Apr 4;276(5309):75-81
pubmed: 9082989
Bioorg Med Chem. 2016 Jun 1;24(11):2466-75
pubmed: 27117263
Drug Discov Today. 2017 Oct;22(10):1582-1592
pubmed: 28711364
J Cosmet Dermatol. 2018 Jun;17(3):461-466
pubmed: 29607625
Biomed Environ Sci. 2009 Feb;22(1):32-9
pubmed: 19462685
J Biomed Biotechnol. 2009;2009:595126
pubmed: 19918372
Cancer Res Treat. 2014 Jan;46(1):2-18
pubmed: 24520218
Anticancer Res. 2001 Jul-Aug;21(4B):2895-900
pubmed: 11712783
Melanoma Res. 2007 Oct;17(5):274-83
pubmed: 17885582
Methods Mol Biol. 2008;443:365-82
pubmed: 18446297
Arch Oral Biol. 2013 Oct;58(10):1343-8
pubmed: 23778072
Hautarzt. 2002 Nov;53(11):718-23
pubmed: 12402133
J Exp Clin Cancer Res. 2018 Dec 5;37(1):303
pubmed: 30518397
Wound Repair Regen. 1995 Jul-Sep;3(3):330-9
pubmed: 17173560
J Cell Physiol. 2019 Aug;234(8):12537-12550
pubmed: 30623450
Int J Clin Pharmacol Ther. 2015 Jan;53(1):54-65
pubmed: 25500488
J Pharm Sci. 2011 Jan;100(1):174-85
pubmed: 20575064
Nutrients. 2018 Jul 01;10(7):
pubmed: 29966389
Nutr J. 2017 Oct 11;16(1):68
pubmed: 29020971
Expert Opin Drug Deliv. 2014 Aug;11(8):1183-201
pubmed: 24857605
Dermatol Surg. 1996 Mar;22(3):217-26
pubmed: 8599733
Mol Pharm. 2012 Oct 1;9(10):2801-11
pubmed: 22946786
Curr Pharm Des. 2013;19(11):1966-73
pubmed: 23116307
Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1149-56
pubmed: 19473187
Cancer Res. 2019 May 1;79(9):2367-2378
pubmed: 30858154
Clin Cancer Res. 2004 Oct 15;10(20):6847-54
pubmed: 15501961
Chem Biol Interact. 2015 Jan 5;225:21-31
pubmed: 25446495
Wound Repair Regen. 1998 Mar-Apr;6(2):167-77
pubmed: 9776860
Phytother Res. 2016 Aug;30(8):1243-64
pubmed: 27213821
J Cell Sci. 1995 Mar;108 ( Pt 3):985-1002
pubmed: 7542672
Chem Pharm Bull (Tokyo). 2012;60(9):1118-24
pubmed: 22976319