Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope.
MSNA variability
baroreceptors
blood pressure variability
heart rate variability
muscle sympathetic nerve activity
power spectrum analysis
syncope
vasovagal
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
10 Sep 2019
10 Sep 2019
Historique:
received:
01
08
2019
revised:
04
09
2019
accepted:
05
09
2019
entrez:
13
9
2019
pubmed:
13
9
2019
medline:
13
9
2019
Statut:
epublish
Résumé
We hypothesized that sympathetic baroreflex mediated uncoupling between neural sympathetic discharge pattern and arterial pressure (AP) fluctuations at 0.1 Hz during baroreceptor unloading might promote orthostatic pre-syncope. Ten volunteers (32 ± 6 years) underwent electrocardiogram, beat-to-beat AP, respiratory activity and muscle sympathetic nerve activity (MSNA) recordings while supine (REST) and during 80° head-up tilt (HUT) followed by -10 mmHg stepwise increase of lower body negative pressure until pre-syncope. Cardiac and sympathetic baroreflex sensitivity were quantified. Spectrum analysis of systolic and diastolic AP (SAP and DAP) and calibrated MSNA (cMSNA) variability assessed the low frequency fluctuations (LF, ~0.1 Hz) of SAP, DAP and cMSNA variability. The squared coherence function (K
Identifiants
pubmed: 31510103
pii: jcm8091434
doi: 10.3390/jcm8091434
pmc: PMC6781174
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL056693
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142583
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL142583
Pays : United States
Références
Circulation. 2000 Dec 5;102(23):2898-906
pubmed: 11104751
Circulation. 1997 Mar 18;95(6):1441-8
pubmed: 9118511
Cardiol Clin. 2013 Feb;31(1):75-87
pubmed: 23217689
J Am Coll Cardiol. 2008 Jan 22;51(3):276-83
pubmed: 18206736
J Appl Physiol (1985). 2013 Jan 15;114(2):203-10
pubmed: 23195626
Auton Neurosci. 2002 Jan 10;95(1-2):141-5
pubmed: 11871780
J Physiol. 2012 Apr 15;590(8):1839-48
pubmed: 22331415
J Physiol. 1994 Jan 15;474(2):331-8
pubmed: 8006818
Circulation. 1996 Mar 1;93(5):1043-65
pubmed: 8598068
Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1238-45
pubmed: 23934851
Am J Physiol. 1985 Jan;248(1 Pt 2):H151-3
pubmed: 3970172
Front Physiol. 2016 Sep 29;7:438
pubmed: 27746741
Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H816-22
pubmed: 20008270
Hypertension. 1988 Aug;12(2):214-22
pubmed: 3410530
Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1804-9
pubmed: 11959646
Am J Physiol. 1988 Feb;254(2 Pt 2):H377-83
pubmed: 3344828
Clin Auton Res. 2004 Feb;14(1):30-3
pubmed: 15045598
Circulation. 1997 Oct 21;96(8):2509-13
pubmed: 9355886
Auton Neurosci. 2001 Jul 20;90(1-2):83-8
pubmed: 11485296
Eur Heart J. 2014 Sep 1;35(33):2211-2
pubmed: 24980488
J Appl Physiol (1985). 2013 Oct 1;115(7):1032-42
pubmed: 23869064
Eur Heart J. 2018 Jun 1;39(21):1883-1948
pubmed: 29562304
Physiol Meas. 2011 Nov;32(11):1775-86
pubmed: 22027399
Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1758-69
pubmed: 15937091
Physiol Meas. 2015 Apr;36(4):633-41
pubmed: 25798786
Circulation. 2000 Feb 29;101(8):886-92
pubmed: 10694528
Am J Med Sci. 2007 Jul;334(1):80-5
pubmed: 17630598
Hypertension. 1997 Nov;30(5):1072-7
pubmed: 9369258
J Clin Invest. 1997 Jun 1;99(11):2736-44
pubmed: 9169504
J Physiol. 1985 Aug;365:181-96
pubmed: 4032310
Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1758-65
pubmed: 19363133
Hypertension. 2005 May;45(5):834-9
pubmed: 15837841
Auton Neurosci. 2012 Dec 24;172(1-2):1-3
pubmed: 23167992
Hypertension. 2007 Jan;49(1):120-6
pubmed: 17101845
Hypertension. 1995 Jun;25(6):1276-86
pubmed: 7768574
Clin Sci (Lond). 2004 Jul;107(1):55-61
pubmed: 14982493
N Engl J Med. 1993 Nov 11;329(20):1449-55
pubmed: 8413455
Am J Physiol. 1998 Apr;274(4):H1277-83
pubmed: 9575932
J Appl Physiol (1985). 2001 Sep;91(3):1199-206
pubmed: 11509516
Eur Heart J. 2010 Aug;31(16):2027-33
pubmed: 20304836
J Physiol. 2006 Nov 1;576(Pt 3):947-58
pubmed: 16916904
Circ Res. 1986 Aug;59(2):178-93
pubmed: 2874900
Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1;310(11):R1134-43
pubmed: 27009053
Am J Physiol. 1969 Sep;217(3):703-9
pubmed: 5807693
J Physiol. 2009 Oct 15;587(Pt 20):4987-99
pubmed: 19703962
Clin Auton Res. 1994 Apr;4(1-2):41-7
pubmed: 8054836