AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.
Angiotensin II Type 1 Receptor Blockers
/ therapeutic use
Animals
Benzimidazoles
/ therapeutic use
Biphenyl Compounds
/ therapeutic use
Cells, Cultured
Fibrosis
Humans
Kidney
/ pathology
Male
Mice
Mice, Inbred C57BL
Myocardium
/ pathology
Myofibroblasts
/ physiology
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1
/ physiology
Receptor, Angiotensin, Type 2
/ agonists
Receptors, G-Protein-Coupled
/ agonists
Receptors, Peptide
/ agonists
Recombinant Proteins
Relaxin
/ physiology
Tetrazoles
/ therapeutic use
Relaxin family peptide receptor 1
angiotensin receptors
fibrosis
heart disease
kidney disease
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
14
06
2019
accepted:
29
07
2019
pubmed:
13
9
2019
medline:
2
6
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated We examined the signal transduction mechanisms of serelaxin when applied to primary rat renal and human cardiac myofibroblasts The AT These findings have significant implications for the concomitant use of RXFP1 or AT
Sections du résumé
BACKGROUND
Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated
METHODS
We examined the signal transduction mechanisms of serelaxin when applied to primary rat renal and human cardiac myofibroblasts
RESULTS
The AT
CONCLUSIONS
These findings have significant implications for the concomitant use of RXFP1 or AT
Identifiants
pubmed: 31511361
pii: ASN.2019060597
doi: 10.1681/ASN.2019060597
pmc: PMC6830801
doi:
Substances chimiques
Angiotensin II Type 1 Receptor Blockers
0
Benzimidazoles
0
Biphenyl Compounds
0
RXFP1 protein, human
0
Receptor, Angiotensin, Type 1
0
Receptor, Angiotensin, Type 2
0
Receptors, G-Protein-Coupled
0
Receptors, Peptide
0
Recombinant Proteins
0
Tetrazoles
0
serelaxin protein, human
0
Relaxin
9002-69-1
candesartan cilexetil
R85M2X0D68
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2191-2207Informations de copyright
Copyright © 2019 by the American Society of Nephrology.
Références
Kidney Int. 1999 Sep;56(3):898-909
pubmed: 10469358
Endocrinology. 2004 Mar;145(3):1106-12
pubmed: 14630720
Endocrinology. 2004 Sep;145(9):4125-33
pubmed: 15155573
J Clin Invest. 1997 Jul 15;100(2):264-9
pubmed: 9218502
Kidney Int. 1997 Dec;52(6):1497-510
pubmed: 9407495
Pharmacol Res. 2008 Jan;57(1):43-8
pubmed: 18068999
J Clin Invest. 1996 Dec 15;98(12):2739-45
pubmed: 8981919
Eur Heart J. 1994 Dec;15 Suppl D:92-7
pubmed: 7713121
Regul Pept. 2011 Jan 17;166(1-3):76-82
pubmed: 20851151
Pharmacol Ther. 2008 Dec;120(3):292-316
pubmed: 18804122
Int J Hypertens. 2012;2012:543062
pubmed: 22500216
PLoS One. 2012;7(8):e42714
pubmed: 22936987
PLoS One. 2018 Jan 18;13(1):e0190935
pubmed: 29346407
Front Pharmacol. 2017 Aug 31;8:564
pubmed: 28912715
Physiol Rev. 2013 Jan;93(1):405-80
pubmed: 23303914
Am J Physiol Renal Physiol. 2014 Nov 15;307(10):F1123-31
pubmed: 25186297
Eur J Pharmacol. 2017 Mar 15;799:128-134
pubmed: 28192099
Cell Mol Life Sci. 2014 Feb;71(4):549-74
pubmed: 23649149
J Biol Chem. 1990 Jun 25;265(18):10681-5
pubmed: 2162358
Am J Med Sci. 2003 Jul;326(1):15-24
pubmed: 12861121
Kidney Int. 2005 Jul;68(1):96-109
pubmed: 15954899
Curr Opin Nephrol Hypertens. 2017 Jan;26(1):36-42
pubmed: 27798458
Br J Pharmacol. 2003 Nov;140(5):809-24
pubmed: 14530223
Am J Physiol Renal Physiol. 2009 Jun;296(6):F1239-44
pubmed: 19144691
Nephrology (Carlton). 2010 Apr;15(3):327-35
pubmed: 20470302
Gene. 2012 Apr 15;497(2):301-6
pubmed: 22326534
Reproduction. 2017 Jul;154(1):67-77
pubmed: 28468839
Clin Sci (Lond). 2011 Oct;121(7):297-303
pubmed: 21542804
J Clin Invest. 1996 Apr 15;97(8):1978-82
pubmed: 8621783
Front Pharmacol. 2016 Mar 31;7:91
pubmed: 27065874
Hum Reprod Update. 2016 Sep;22(5):647-64
pubmed: 27385360
J Nephrol. 2011 Sep-Oct;24(5):569-80
pubmed: 21404225
Physiol Rev. 1975 Jul;55(3):418-87
pubmed: 50603
Am J Pathol. 2011 Dec;179(6):2751-65
pubmed: 21983071
Oncotarget. 2017 Mar 28;8(13):21044-21053
pubmed: 28416741
Hypertension. 2014 Aug;64(2):315-22
pubmed: 24866131
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10663-7
pubmed: 7479861
Am J Hypertens. 2004 Aug;17(8):684-9
pubmed: 15288884
Hypertension. 2005 May;45(5):840-4
pubmed: 15738342
Gut. 2001 Oct;49(4):577-83
pubmed: 11559657
Trends Pharmacol Sci. 2016 Jun;37(6):485-497
pubmed: 26996448
Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1355-62
pubmed: 25298524
Clin Sci (Lond). 1997 Sep;93(3):191-4
pubmed: 9337632
Int Rev Cytol. 2007;257:143-79
pubmed: 17280897
FASEB J. 2003 Jan;17(1):121-3
pubmed: 12424226
Chem Sci. 2016 Jun 1;7(6):3805-3819
pubmed: 30155023
Lancet. 2013 Jan 5;381(9860):29-39
pubmed: 23141816
Br J Pharmacol. 2015 Feb;172(4):1005-19
pubmed: 25297987
Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F901-7
pubmed: 25164079
Front Pharmacol. 2016 Mar 31;7:76
pubmed: 27065866
J Am Soc Nephrol. 2006 May;17(5):1325-33
pubmed: 16597680
Diabetologia. 2016 Aug;59(8):1778-90
pubmed: 27168137
Cell Signal. 2011 Nov;23(11):1767-76
pubmed: 21740964
J Am Soc Nephrol. 1998 Apr;9(4):632-42
pubmed: 9555666
Cardiovasc Drugs Ther. 2014 Jun;28(3):221-8
pubmed: 24852484
Comp Med. 2009 Aug;59(4):339-43
pubmed: 19712573
Kidney Int Suppl. 1997 Dec;63:S111-4
pubmed: 9407436
Ann N Y Acad Sci. 2009 Apr;1160:54-9
pubmed: 19416159
Kidney Int. 2014 Jul;86(1):75-85
pubmed: 24429402
Endocrinology. 2010 Oct;151(10):4938-48
pubmed: 20826562
Hypertension. 2008 Oct;52(4):666-71
pubmed: 18711010
Sci Rep. 2017 Jun 7;7(1):2968
pubmed: 28592882
Amino Acids. 2010 Jul;39(2):409-16
pubmed: 20043231
Eur J Heart Fail. 2017 Jun;19(6):800-809
pubmed: 28452195
Cardiovasc Drugs Ther. 2004 Sep;18(5):353-62
pubmed: 15717137
FASEB J. 2009 Apr;23(4):1219-29
pubmed: 19073841
J Clin Endocrinol Metab. 2011 Nov;96(11):3517-24
pubmed: 21880804
J Card Fail. 2011 Feb;17(2):158-66
pubmed: 21300306
Endocrinology. 2008 Feb;149(2):476-82
pubmed: 17991721
Kidney Int. 2009 Jun;75(11):1145-1152
pubmed: 19340094
Transl Res. 2009 Jul;154(1):1-6
pubmed: 19524867
Nat Med. 2012 Jul 06;18(7):1028-40
pubmed: 22772564
Hypertension. 2012 Feb;59(2):291-9
pubmed: 22184324
Circ J. 2014;78(3):542-52
pubmed: 24451687
Ther Adv Cardiovasc Dis. 2016 Jun;10(3):151-61
pubmed: 27122491
J Hypertens. 2012 Jun;30(6):1176-84
pubmed: 22504846