Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 09 2019
11 09 2019
Historique:
received:
28
03
2019
accepted:
21
08
2019
entrez:
13
9
2019
pubmed:
13
9
2019
medline:
5
11
2020
Statut:
epublish
Résumé
In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization, and translation. A subset of maternal transcripts is stored in a translationally dormant state in the oocyte, and temporally driven translation of specific mRNAs propel meiotic progression, oocyte-to-embryo transition and early embryo development. We identified Ank2.3 as the only transcript variant present in the mouse oocyte and discovered that it is translated after nuclear envelope breakdown. Here we show that Ank2.3 mRNA is localized in higher concentration in the oocyte nucleoplasm and, after nuclear envelope breakdown, in the newly forming spindle where its translation occurs. Furthermore, we reveal that Ank2.3 mRNA contains an oligo-pyrimidine motif at 5'UTR that predetermines its translation through a cap-dependent pathway. Lastly, we show that prevention of ANK2 translation leads to abnormalities in oocyte cytokinesis.
Identifiants
pubmed: 31511568
doi: 10.1038/s41598-019-49483-5
pii: 10.1038/s41598-019-49483-5
pmc: PMC6739377
doi:
Substances chimiques
Ank2 protein, mouse
0
Ankyrins
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13121Commentaires et corrections
Type : ErratumIn
Type : ErratumIn
Références
Mol Reprod Dev. 2008 Dec;75(12):1716-25
pubmed: 18386287
Nature. 1988 May 12;333(6169):177-80
pubmed: 2452986
Development. 2009 Sep;136(18):3033-42
pubmed: 19700615
J Cell Sci. 2018 Nov 22;131(22):
pubmed: 30467138
J Cell Biochem. 1985;29(2):157-69
pubmed: 2933418
Results Probl Cell Differ. 2017;63:257-295
pubmed: 28779322
Science. 2011 Dec 16;334(6062):1524-9
pubmed: 22096102
Nat Cell Biol. 2011 Aug 28;13(10):1252-8
pubmed: 21874009
Curr Biol. 2000 Oct 19;10(20):1303-6
pubmed: 11069114
Nature. 2012 May 02;485(7396):109-13
pubmed: 22552098
J Biol Chem. 1984 Dec 10;259(23):14829-34
pubmed: 6094578
Biol Cell. 2005 Jan;97(1):19-33
pubmed: 15601255
Nat Methods. 2015 May;12(5):411-4
pubmed: 25775042
Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82
pubmed: 25883264
Nucleic Acids Res. 1997 Mar 1;25(5):995-1001
pubmed: 9023110
Mol Reprod Dev. 1995 Apr;40(4):467-80
pubmed: 7598913
PLoS One. 2018 Mar 12;13(3):e0192544
pubmed: 29529035
RNA. 2008 Jul;14(7):1318-27
pubmed: 18515545
PLoS Biol. 2008 Oct 28;6(10):e255
pubmed: 18959479
Cell Cycle. 2017 May 19;16(10):927-939
pubmed: 28272965
Nat Commun. 2016 Jan 04;7:10253
pubmed: 26727405
Dev Biol. 1980 Jan;74(1):1-8
pubmed: 7350004
Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C501-C515
pubmed: 28794108
Int J Oncol. 2010 Jan;36(1):107-15
pubmed: 19956839
Cell. 2009 Feb 20;136(4):719-30
pubmed: 19239891
Dev Biol. 1988 Apr;126(2):242-52
pubmed: 3350209
Mol Reprod Dev. 2008 Feb;75(2):309-17
pubmed: 17290414
BMC Biol. 2014 Aug 15;12:55
pubmed: 25124741
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3319-23
pubmed: 2014251
Nat Commun. 2015 Jan 28;6:6078
pubmed: 25629602
Science. 2018 Mar 23;359(6382):1416-1421
pubmed: 29567716
Bioessays. 1993 Aug;15(8):531-8
pubmed: 8135766
Mol Reprod Dev. 1995 Aug;41(4):449-58
pubmed: 7576612
Mol Reprod Dev. 2014 Apr;81(4):363-75
pubmed: 24459013
EMBO J. 1997 Jun 16;16(12):3693-704
pubmed: 9218810
Cell. 2007 Oct 5;131(1):174-87
pubmed: 17923096
Genome Biol. 2001;2(5):REVIEWS1015
pubmed: 11387041
Curr Opin Cell Biol. 1995 Jun;7(3):386-92
pubmed: 7662369
Elife. 2015 Apr 02;4:
pubmed: 25838129
Dev Cell. 2013 Mar 11;24(5):517-29
pubmed: 23434411
J Cell Biol. 2016 Sep 12;214(6):769-81
pubmed: 27597760
Nat Struct Mol Biol. 2004 Apr;11(4):346-51
pubmed: 15034551
J Embryol Exp Morphol. 1985 Nov;89 Suppl:333-47
pubmed: 3831218
Mech Dev. 1998 Jan;70(1-2):193-5
pubmed: 9510035
Cell. 2009 Feb 20;136(4):731-45
pubmed: 19239892
Genetics. 2013 Oct;195(2):349-58
pubmed: 23852387
Nucleic Acids Res. 2019 Jan 10;47(1):328-340
pubmed: 30335155
Biochem Biophys Res Commun. 2012 Dec 7;429(1-2):57-62
pubmed: 23131551
Biol Cell. 2009 Feb;101(2):69-76
pubmed: 19076067
Cell Rep. 2015 Dec 29;13(12):2653-62
pubmed: 26711333
EMBO J. 2011 May 4;30(9):1841-51
pubmed: 21468028
J Cell Biol. 2015 Aug 31;210(5):695-704
pubmed: 26304726
Mol Reprod Dev. 2013 Apr;80(4):334-48
pubmed: 23440873
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 22865893
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4036-45
pubmed: 26170285
BMC Genomics. 2007 Feb 01;8:39
pubmed: 17270048
J Biol Chem. 1998 May 22;273(21):13015-21
pubmed: 9582337
PLoS One. 2011;6(7):e21415
pubmed: 21750711
Sci Rep. 2018 May 21;8(1):7930
pubmed: 29785002
Nat Commun. 2017 Oct 11;8(1):849
pubmed: 29021609
Biochem Soc Trans. 2015 Dec;43(6):1277-84
pubmed: 26614673
J Cell Biol. 2007 Dec 31;179(7):1365-73
pubmed: 18166649
Curr Biol. 2001 Sep 4;11(17):1374-9
pubmed: 11553333
J Mol Cell Cardiol. 2008 Dec;45(6):709-11
pubmed: 18838078
Biol Reprod. 2002 May;66(5):1274-82
pubmed: 11967187
Science. 2004 Jul 2;305(5680):61-6
pubmed: 15166316
Sci Rep. 2017 Oct 3;7(1):12607
pubmed: 28974707
Dev Biol. 2004 Nov 15;275(2):447-58
pubmed: 15501230
Dev Biol. 1981 Sep;86(2):373-83
pubmed: 6169567
RNA. 2004 Feb;10(2):200-9
pubmed: 14730019
Science. 2009 Nov 27;326(5957):1212-6
pubmed: 19965463
Biochim Biophys Acta. 1969 Nov 19;195(1):76-86
pubmed: 4982427