Serum proteome of dogs at subclinical and clinical onset of canine leishmaniosis.
Leishmania
SWATH-MS
biomarkers
dog diseases
proteomics
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
25
04
2019
revised:
08
08
2019
accepted:
30
08
2019
pubmed:
13
9
2019
medline:
27
5
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
The objective of this study was to identify changes in serum proteome in dogs that may occur after an experimental infection at subclinical and clinical stages of canine leishmaniosis (CanL). For this purpose, canine pre- and post-infection with Leishmania infantum serum proteomes in the same dogs were analysed by a high-throughput label-based quantitative LC-MS/MS proteomic approach. A total of 169 proteins were identified, and 74 of them including complement C8 alpha chain, adiponectin, transferrin, sphingomyelin phosphodiesterase acid-like 3A and immunoglobulins showed different modulation between the different stages of CanL. These proteins could be considered as potential serum biomarkers of early diagnostic or disease progression in CanL. Additionally, biological pathways modulated during CanL such as blood coagulation or gonadotropin-releasing hormone receptor were revealed, which could help to understand the pathological mechanisms of the disease.
Substances chimiques
Biomarkers
0
Proteome
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
318-327Subventions
Organisme : Ramón y Cajal
Organisme : Programa Estatal I+D+I
Organisme : Research Plan of University of Castilla- La Mancha
Organisme : Program for Research Groups of Excellence
Organisme : Predoctoral grant FPU, University of Murcia
Informations de copyright
© 2019 Blackwell Verlag GmbH.
Références
Artigas-Jerónimo, S., De La Fuente, J., & Villar, M. (2018). Interactomics and tick vaccine development: New directions for the control of tick-borne diseases. Expert Review of Proteomics, 15(8), 627-635. https://doi.org/10.1080/14789450.2018.1506701
Ashford, D. A., Badaro, R., Eulalio, C., Freire, M., Miranda, C., Zalis, M. G., & David, J. R. (1993). Studies on the control of visceral leishmaniasis: Validation of the Falcon assay screening test-enzyme-linked immunosorbent assay (FAST-ELISA(TM)) for field diagnosis of canine visceral leishmaniasis. In American Journal of Tropical Medicine and Hygiene. 48:1-8.
Berg, A. H., & Scherer, P. E. (2005). Adipose tissue, inflammation, and cardiovascular disease. Circulation Research, 96(9), 939-949. https://doi.org/10.1161/01.RES.0000163635.62927.34
Burillo, F. L., Perez, F. M. G., Liesa, J. P., & Fabian, M. C. A. (1994). Iron status and anemia in canine leishmaniasis. Revue De Medecine Veterinaire, 145(3), 171-176.
Cantos-Barreda, A., Escribano, D., Cerón, J. J., Bernal, L. J., Furlanello, T., Tecles, F., … Martínez-Subiela, S. (2018). Relationship between serum anti-Leishmania antibody levels and acute phase proteins in dogs with canine leishmaniosis. Veterinary Parasitology, 260, 63-68. https://doi.org/10.1016/J.VETPAR.2018.08.010
Cerón, J. J., Eckersall, P. D., & Martínez-Subiela, S. (2005). Acute phase proteins in dogs and cats: Current knowledge and future perspectives. Veterinary Clinical Pathology, 34(2), 85-99. https://doi.org/10.1111/j.1939-165X.2005.tb00019.x
Contreras, M., Villar, M., Artigas-Jerónimo, S., Kornieieva, L., Mytrofanov, S., & de la Fuente, J. (2018). A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations. Parasites & Vectors, 11(1), 43. https://doi.org/10.1186/s13071-018-2618-x
de Amorim, I. F. G., Da Silva, S. M., Figueiredo, M. M., Moura, E. P., de Castro, R. S., de Souza Lima, T. K., … Tafuri, W. L. (2011). Toll receptors type-2 and CR3 expression of canine monocytes and its correlation with immunohistochemistry and xenodiagnosis in visceral leishmaniasis. PLoS ONE, 6(11), e27679. https://doi.org/10.1371/journal.pone.0027679
Escribano, D., Tvarijonaviciute, A., Kocaturk, M., Cerón, J. J., Pardo-Marín, L., Torrecillas, A., … Martínez-Subiela, S. (2016). Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis. Comparative Immunology, Microbiology and Infectious Diseases, 49, 82-87. https://doi.org/10.1016/j.cimid.2016.10.002
Franco-Martínez, L., Tvarijonaviciute, A., Horvatić, A., Guillemin, N., Cerón, J. J., Escribano, D., … Mrljak, V. (2018). Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study. Comparative Immunology, Microbiology and Infectious Diseases, 60, 1-10. https://doi.org/10.1016/J.CIMID.2018.09.011
Gillet, L. C., Navarro, P., Tate, S., Röst, H., Selevsek, N., Reiter, L., … Aebersold, R. (2012). Targeted data extraction of the MS/MS spectra generated by data-independent acquisition: A new concept for consistent and accurate proteome analysis. Molecular & Cellular Proteomics, 11(6), O111.016717. https://doi.org/10.1074/mcp.O111.016717
Hadders, M. A., Beringer, D. X., & Gros, P. (2007). Structure of C8α-MACPF reveals mechanism of membrane attack in complement immune defense. Science, 317, 1552-1554.https://doi.org/10.1126/science.1147103
Kim, A. Y., Kim, H.-S., Kang, J.-H., & Yang, M.-P. (2015). Serum adipokine concentrations in dogs with diabetes mellitus: A pilot study. Journal of Veterinary Science, 16(3), 333-340. https://doi.org/10.4142/jvs.2015.16.3.333
Kuleš, J., Horvatić, A., Guillemin, N., Galan, A., Mrljak, V., & Bhide, M. (2016). New approaches and omics tools for mining of vaccine candidates against vector-borne diseases. Molecular BioSystems, 12(9), 2680-2694. https://doi.org/10.1039/C6MB00268D
Kuleš, J., Mrljak, V., Barić Rafaj, R., Selanec, J., Burchmore, R., & Eckersall, P. D. (2014). Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach. BMC Veterinary Research, 10, 111. https://doi.org/10.1186/1746-6148-10-111
Martinez-Subiela, S., & Cerón, J. J. (2005). Validation of commercial assays for the determination of haptoglobin, C-reactive protein and serum amyloid A in dogs. Archivos De Medicina Veterinaria, 37, 60-67.
Martínez-Subiela, S., Ceron, J. J., Yilmaz, Z., Martinez-Subiela, S., Horvatic, A., Escribano, D., … Yilmaz, Z. (2017). Identification of novel biomarkers for treatment monitoring in canine leishmaniosis by high-resolution quantitative proteomic analysis. Veterinary Immunology and Immunopathology, 191, 60-67. https://doi.org/10.1016/j.cimid.2016.10.002
Martinez-Subiela, S., Strauss-Ayali, D., Cerón, J. J., & Baneth, G. (2011). Acute phase protein response in experimental canine leishmaniosis. Veterinary Parasitology, 180, 197-202. https://doi.org/10.1016/j.vetpar.2011.03.032
Miró, G., Petersen, C., Cardoso, L., Bourdeau, P., Baneth, G., Solano-Gallego, L., … Oliva, G. (2017). Novel Areas for Prevention and Control of Canine Leishmaniosis. Trends in Parasitology, 33(9), 718-730. https://doi.org/10.1016/j.pt.2017.05.005
Nabity, M. B., Lees, G. E., Dangott, L. J., Cianciolo, R., Suchodolski, J. S., & Steiner, J. M. (2011). Proteomic analysis of urine from male dogs during early stages of tubulointerstitial injury in a canine model of progressive glomerular disease. Veterinary Clinical Pathology, 40(2), 222-236. https://doi.org/10.1111/j.1939-165X.2011.00307.x
Paek, J., Kang, J. H., Kim, H. S., Lee, I., Seo, K. W., & Yang, M. P. (2014). Serum adipokine concentrations in dogs with acute pancreatitis. Journal of Veterinary Internal Medicine, 28(6), 1760-1769. https://doi.org/10.1111/jvim.12437
Paltrinieri, S., Gradoni, L., Roura, X., Zatelli, A., & Zini, E. (2016). Laboratory tests for diagnosing and monitoring canine leishmaniasis. Veterinary Clinical Pathology, 45(4), 552-578. https://doi.org/10.1111/vcp.12413
Paltrinieri, S., Solano-Gallego, L., Fondati, A., Lubas, G., Gradoni, L., Castagnaro, M., … Zini, E. (2010). Guidelines for diagnosis and clinical classification of leishmaniasis in dogs. Journal of the American Veterinary Medical Association, 236(11), 1184-1191. https://doi.org/10.2460/javma.236.11.1184
Silva-Barrios, S., Smans, M., Duerr, C. U., Qureshi, S. T., Fritz, J. H., Descoteaux, A., & Stäger, S. (2016). Innate immune B cell activation by Leishmania donovani Exacerbates disease and mediates hypergammaglobulinemia. Cell Reports, 15(11), 2427-2437. https://doi.org/10.1016/j.celrep.2016.05.028
Silvestrini, P., Zoia, A., Planellas, M., Roura, X., Pastor, J., Cerón, J. J., & Caldin, M. (2014). Iron status and C-reactive protein in canine leishmaniasis. Journal of Small Animal Practice, 55(2), 95-101. https://doi.org/10.1111/jsap.12172
Solano-Gallego, L., Koutinas, A., Miró, G., Cardoso, L., Pennisi, M. G., Ferrer, L., … Baneth, G. (2009). Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis. Veterinary Parasitology, 165(1-2), 1-18. https://doi.org/10.1016/J.VETPAR.2009.05.022
Solano-Gallego, L., Miró, G., Koutinas, A., Cardoso, L., Pennisi, M., Ferrer, L., … Baneth, G. (2011). LeishVet guidelines for the practical management of canine leishmaniosis. Parasites & Vectors, 4(1), 86. https://doi.org/10.1186/1756-3305-4-86
Solano-Gallego, L., Villanueva-Saz, S., Carbonell, M., Trotta, M., Furlanello, T., & Natale, A. (2014). Serological diagnosis of canine leishmaniosis: Comparison of three commercial ELISA tests (Leiscan®, ID Screen® and Leishmania 96®), a rapid test (Speed Leish K®) and an in-house IFAT. Parasites and Vectors, 7(1), 111. https://doi.org/10.1186/1756-3305-7-111
Solbach, W., & Laskay, T. (1999). The host response to leishmania infection. Advances in Immunology, 74, 275-317. https://doi.org/10.1016/S0065-2776(08)60912-8
Traini, M., Quinn, C. M., Sandoval, C., Johansson, E., Schroder, K., Kockx, M., … Kritharides, L. (2014). Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. Journal of Biological Chemistry, 289(47), 32895-32913. https://doi.org/10.1074/jbc.M114.612341
Tvarijonaviciute, A., Ceron, J. J., Holden, S. L., Cuthbertson, D. J., Biourge, V., Morris, P. J., & German, A. J. (2012). Obesity-related metabolic dysfunction in dogs: A comparison with human metabolic syndrome. BMC Veterinary Research, 8, 147. https://doi.org/10.1186/1746-6148-8-147
Villar, M., Ayllón, N., Alberdi, P., Moreno, A., Moreno, M., Tobes, R., … de la Fuente, J. (2015). Integrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells. Molecular & Cellular Proteomics: MCP, 14(12), 3154-3172. https://doi.org/10.1074/mcp.M115.051938
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., … Kadowaki, T. (2002). Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine, 8(11), 1288-1295. https://doi.org/10.1038/nm788