TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish.
Hippo pathway
Left-Right Organizer
Left-Right asymmetry
Taz
Vgll4
Yap
developmental biology
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 09 2019
12 09 2019
Historique:
received:
16
01
2019
accepted:
11
09
2019
pubmed:
13
9
2019
medline:
12
2
2020
entrez:
13
9
2019
Statut:
epublish
Résumé
In many vertebrates, establishment of Left-Right (LR) asymmetry results from the activity of a ciliated organ functioning as the LR Organizer (LRO). While regulation of the formation of this structure by major signaling pathways has been described, the transcriptional control of LRO formation is poorly understood. Using the zebrafish model, we show that the transcription factors and cofactors mediating or regulating the transcriptional outcome of the Hippo signaling pathway play a pivotal role in controlling the expression of genes essential to the formation of the LRO including ligands and receptors of signaling pathways involved in this process and most genes required for motile ciliogenesis. Moreover, the transcription cofactor, Vgll4l regulates epigenetic programming in LRO progenitors by controlling the expression of writers and readers of DNA methylation marks. Altogether, our study uncovers a novel and essential role for the transcriptional effectors and regulators of the Hippo pathway in establishing LR asymmetry.
Identifiants
pubmed: 31513014
doi: 10.7554/eLife.45241
pii: 45241
pmc: PMC6759317
doi:
pii:
Substances chimiques
Transcription Factors
0
Banques de données
GEO
['GSE119623']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM110092
Pays : United States
Organisme : NIH HHS
ID : R01GM110092
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM132131
Pays : United States
Organisme : National Science Foundation
ID : 1455901
Pays : International
Organisme : NIH HHS
ID : R01GM132131
Pays : United States
Informations de copyright
© 2019, Fillatre et al.
Déclaration de conflit d'intérêts
JF, JF, JF, CL, MG, CT, BT No competing interests declared
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