Mechanisms of nuclear mRNA export: A structural perspective.
DEAD-box ATPase
export receptor
mRNA export
mRNP remodeling
structural biology
Journal
Traffic (Copenhagen, Denmark)
ISSN: 1600-0854
Titre abrégé: Traffic
Pays: England
ID NLM: 100939340
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
14
08
2019
accepted:
26
08
2019
pubmed:
13
9
2019
medline:
1
7
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
Export of mRNA from the nucleus to the cytoplasm is a critical process for all eukaryotic gene expression. As mRNA is synthesized, it is packaged with a myriad of RNA-binding proteins to form ribonucleoprotein particles (mRNPs). For each step in the processes of maturation and export, mRNPs must have the correct complement of proteins. Much of the mRNA export pathway revolves around the heterodimeric export receptor yeast Mex67•Mtr2/human NXF1•NXT1, which is recruited to signal the completion of nuclear mRNP assembly, mediates mRNP targeting/translocation through the nuclear pore complex (NPC), and is displaced at the cytoplasmic side of the NPC to release the mRNP into the cytoplasm. Directionality of the transport is governed by at least two DEAD-box ATPases, yeast Sub2/human UAP56 in the nucleus and yeast Dbp5/human DDX19 at the cytoplasmic side of the NPC, which respectively mediate the association and dissociation of Mex67•Mtr2/NXF1•NXT1 onto the mRNP. Here we review recent progress from structural studies of key constituents in different steps of nuclear mRNA export. These findings have laid the foundation for further studies to obtain a comprehensive mechanistic view of the mRNA export pathway.
Identifiants
pubmed: 31513326
doi: 10.1111/tra.12691
pmc: PMC7074880
mid: NIHMS1570473
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-840Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133743
Pays : United States
Organisme : NIGMS NIH HHS
ID : 1R35GM133743-01
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Cell. 2015 Aug 27;162(5):1016-28
pubmed: 26317468
Curr Biol. 1998 Dec 17-31;8(25):1403-6
pubmed: 9889103
Cell. 2013 Oct 24;155(3):582-93
pubmed: 24243016
EMBO J. 1998 Feb 16;17(4):1107-19
pubmed: 9463388
Cell. 2006 Dec 29;127(7):1389-400
pubmed: 17190602
Genes Dev. 1997 Jul 15;11(14):1864-72
pubmed: 9242493
Mol Cell. 2005 Jan 7;17(1):93-102
pubmed: 15629720
EMBO J. 2004 Jul 7;23(13):2620-31
pubmed: 15192704
Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a000562
pubmed: 20630994
J Cell Biol. 1995 Dec;131(6 Pt 2):1699-713
pubmed: 8557738
Eukaryot Cell. 2009 Dec;8(12):1814-27
pubmed: 19801417
Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73
pubmed: 17786152
Cell. 2008 Aug 22;134(4):624-33
pubmed: 18724935
J Cell Biol. 2006 Nov 6;175(3):415-26
pubmed: 17074885
Cell. 2004 Jan 9;116(1):75-86
pubmed: 14718168
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3089-94
pubmed: 19208808
Nat Cell Biol. 2006 Jul;8(7):668-76
pubmed: 16783364
Genes Dev. 2001 Jan 1;15(1):42-9
pubmed: 11156604
Cell. 1995 Apr 21;81(2):215-22
pubmed: 7736573
Cell. 2013 Aug 29;154(5):996-1009
pubmed: 23993093
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5154-9
pubmed: 18364396
Elife. 2017 Jan 06;6:
pubmed: 28059701
Mol Biol Cell. 1996 Dec;7(12):1921-37
pubmed: 8970155
Structure. 2015 Jul 7;23(7):1246-57
pubmed: 26051714
J Mol Biol. 2008 Feb 29;376(4):1048-59
pubmed: 18190927
Genes Dev. 1997 Nov 1;11(21):2845-56
pubmed: 9353254
Nature. 2001 Oct 11;413(6856):648-52
pubmed: 11675790
Hum Mol Genet. 2015 Mar 1;24(5):1363-73
pubmed: 25343993
Nat Commun. 2014;5:3123
pubmed: 24452287
Nat Rev Mol Cell Biol. 2010 Jul;11(7):490-501
pubmed: 20571586
RNA. 2011 Jul;17(7):1344-56
pubmed: 21613532
Mol Biol Cell. 1998 Feb;9(2):355-73
pubmed: 9450961
EMBO J. 1997 Jun 2;16(11):3256-71
pubmed: 9214641
EMBO J. 2013 Feb 6;32(3):473-86
pubmed: 23299939
Nucleic Acids Res. 2014 Apr;42(8):5043-58
pubmed: 24500206
J Biol Chem. 2001 Mar 2;276(9):6445-52
pubmed: 11104765
Mol Cell. 2009 Mar 27;33(6):727-37
pubmed: 19328066
J Cell Biol. 1997 Jan 27;136(2):241-50
pubmed: 9015297
Nat Cell Biol. 2006 Jul;8(7):711-6
pubmed: 16783363
Curr Biol. 2009 Dec 1;19(22):1918-24
pubmed: 19836239
Nat Cell Biol. 2004 Sep;6(9):840-8
pubmed: 15311284
Nat Commun. 2012;3:1006
pubmed: 22893130
Genes Dev. 2011 May 15;25(10):1065-77
pubmed: 21576266
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9119-24
pubmed: 9256445
Nat Rev Mol Cell Biol. 2015 Jul;16(7):431-42
pubmed: 26081607
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9127-32
pubmed: 24927547
Biochim Biophys Acta. 2012 Jun;1819(6):546-54
pubmed: 22484098
Mol Cell Biol. 2004 Dec;24(23):10479-91
pubmed: 15542855
Nat Microbiol. 2019 Oct;4(10):1671-1679
pubmed: 31263181
Nucleic Acids Res. 2012 May;40(10):4562-73
pubmed: 22307388
Mol Cell. 2014 Jun 5;54(5):751-65
pubmed: 24768538
RNA. 2013 Oct;19(10):1363-71
pubmed: 23962665
Chem Rev. 2013 Nov 13;113(11):8523-45
pubmed: 23731471
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10406-11
pubmed: 20498086
PLoS Genet. 2013 Nov;9(11):e1003914
pubmed: 24244187
Nucleic Acids Res. 2017 May 19;45(9):5577-5585
pubmed: 28334829
J Cell Biol. 2009 Mar 23;184(6):833-46
pubmed: 19289793
Nat Struct Mol Biol. 2004 Jun;11(6):558-66
pubmed: 15133499
Genetics. 2014 Aug;197(4):1213-24
pubmed: 24931410
Genes Dev. 2010 Sep 1;24(17):1927-38
pubmed: 20810649
Nat Struct Mol Biol. 2009 Mar;16(3):247-54
pubmed: 19219046
Cell. 2008 Oct 17;135(2):308-21
pubmed: 18957205
Mol Cell. 2014 Sep 4;55(5):745-57
pubmed: 25192364
Cell. 2012 Nov 9;151(4):871-884
pubmed: 23141543
J Biol Chem. 2002 Mar 8;277(10):7752-60
pubmed: 11779864
EMBO J. 2011 Aug 31;30(17):3457-74
pubmed: 21878989
Mol Biol Cell. 2005 Sep;16(9):4304-15
pubmed: 16000379
Mol Cell. 1998 Apr;1(5):649-59
pubmed: 9660949
Nature. 2002 May 16;417(6886):304-8
pubmed: 11979277
Nature. 2001 Oct 11;413(6856):644-7
pubmed: 11675789
Science. 1999 Jul 2;285(5424):96-100
pubmed: 10390371
Biochem J. 2014 Jan 15;457(2):231-42
pubmed: 24354960
Nucleic Acids Res. 2018 Jul 27;46(13):6561-6575
pubmed: 29912477
Genes Dev. 2005 Jul 1;19(13):1512-7
pubmed: 15998806
Nucleic Acids Res. 2014 Jun;42(10):6686-97
pubmed: 24705649
Nature. 2007 May 24;447(7143):413-7
pubmed: 17522674
Traffic. 2017 Dec;18(12):776-790
pubmed: 28869701
Immunity. 1997 May;6(5):571-82
pubmed: 9175835
Science. 2007 Feb 2;315(5812):646-9
pubmed: 17272721
Nucleic Acids Res. 2015 Feb 18;43(3):1927-36
pubmed: 25618852
Curr Biol. 2010 Jan 12;20(1):25-31
pubmed: 20005110
Viruses. 2013 Jul 18;5(7):1824-49
pubmed: 23872491
Trends Biochem Sci. 2010 Nov;35(11):609-17
pubmed: 20719516
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17628-33
pubmed: 15585580
Nat Rev Mol Cell Biol. 2011 Jul 22;12(8):505-16
pubmed: 21779027
Nucleic Acids Res. 2015 Feb 18;43(3):1883-93
pubmed: 25628361
Nucleic Acids Res. 2015 Feb 18;43(3):1894-904
pubmed: 25628355
Nucleic Acids Res. 2013 Jan;41(2):1294-306
pubmed: 23222130
J Mol Biol. 2003 Feb 21;326(3):849-58
pubmed: 12581645
J Cell Sci. 2009 Jun 15;122(Pt 12):1933-7
pubmed: 19494120
EMBO J. 2000 Nov 1;19(21):5824-34
pubmed: 11060033
Mol Cell. 2013 Sep 26;51(6):737-50
pubmed: 24074953
RNA. 1999 Sep;5(9):1138-9
pubmed: 10496214
Nucleic Acids Res. 2013 Feb 1;41(4):2517-25
pubmed: 23275560
Mol Cell. 2007 Dec 14;28(5):850-9
pubmed: 18082609
Nature. 2001 Feb 15;409(6822):860-921
pubmed: 11237011
Nat Struct Mol Biol. 2011 Sep 25;18(10):1164-71
pubmed: 21947206
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9564-9
pubmed: 18606994
Mol Cell Biol. 2002 Dec;22(23):8241-53
pubmed: 12417727
EMBO J. 2000 Feb 1;19(3):410-20
pubmed: 10722314
Nat Struct Mol Biol. 2012 Feb 19;19(3):328-36
pubmed: 22343721
J Biol Chem. 2009 Apr 17;284(16):10296-300
pubmed: 19244245
Trends Cell Biol. 2013 Jul;23(7):328-35
pubmed: 23582887
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1858-62
pubmed: 14769921
Nat Commun. 2018 Jun 13;9(1):2319
pubmed: 29899397
J Biol Chem. 2011 Nov 18;286(46):39750-9
pubmed: 21949122
Cell Stem Cell. 2013 Dec 5;13(6):676-90
pubmed: 24315442
Cell. 2016 Nov 17;167(5):1215-1228.e25
pubmed: 27839866
EMBO J. 2002 Nov 1;21(21):5843-52
pubmed: 12411502
Nucleic Acids Res. 2014 Jun;42(11):7305-18
pubmed: 24782531
EMBO J. 1999 May 4;18(9):2593-609
pubmed: 10228171
Mol Cell. 2001 Sep;8(3):645-56
pubmed: 11583626
Nature. 2011 Apr 14;472(7342):238-42
pubmed: 21441902
Nature. 2018 Mar 22;555(7697):475-482
pubmed: 29539637
EMBO J. 2012 Mar 21;31(6):1605-16
pubmed: 22314234
J Biol Chem. 2003 Jun 6;278(23):20979-88
pubmed: 12637516
RNA Biol. 2013 Jan;10(1):19-32
pubmed: 22995829
Genes Dev. 1997 Nov 1;11(21):2857-68
pubmed: 9353255
Nat Genet. 2008 Feb;40(2):155-7
pubmed: 18204449
Adv Biol Regul. 2014 Jan;54:74-91
pubmed: 24275432
FEBS Lett. 2008 Jun 18;582(14):1977-86
pubmed: 18342629
Mol Cell. 2009 Jan 30;33(2):215-26
pubmed: 19110458
Mol Cell Biol. 1993 May;13(5):2730-41
pubmed: 8474438
Nat Rev Genet. 2007 Jul;8(7):507-17
pubmed: 17549064
Annu Rev Biochem. 2015;84:325-54
pubmed: 25784054
Cell. 2004 Jan 9;116(1):63-73
pubmed: 14718167
Nature. 2006 Jun 8;441(7094):770-3
pubmed: 16760982