Patient-specific modeling of aerosol delivery in healthy and asthmatic adults.
computational fluid dynamics
conducting airways
dosimetry
hyperpolarized 3He MRI
inhaled medications
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
pubmed:
13
9
2019
medline:
21
10
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
The magnitude and regional heterogeneity of airway obstructions in severe asthmatics is likely linked to insufficient drug delivery, as evidenced by the inability to mitigate exacerbations with inhaled aerosol medications. To understand the correlation between morphometric features, airflow distribution, and inhaled dosimetry, we perform dynamic computational simulations in two healthy and four asthmatic subjects. Models incorporate computed tomography-based and patient-specific central airway geometries and hyperpolarized
Identifiants
pubmed: 31513445
doi: 10.1152/japplphysiol.00221.2019
pmc: PMC6962611
doi:
Substances chimiques
Aerosols
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1720-1732Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL080412
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL109168
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL069116
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL140436
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000427
Pays : United States
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