Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection.
Female
HTLV-I Infections
/ diagnosis
HTLV-II Infections
/ diagnosis
Human T-lymphotropic virus 1
/ isolation & purification
Human T-lymphotropic virus 2
/ isolation & purification
Humans
Immunoassay
/ methods
Pregnancy
Pregnancy Complications
/ virology
Real-Time Polymerase Chain Reaction
/ methods
Viral Load
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
25
04
2019
accepted:
29
08
2019
revised:
27
09
2019
pubmed:
13
9
2019
medline:
11
1
2020
entrez:
13
9
2019
Statut:
epublish
Résumé
Mother-to-child-transmission (MTCT) of human T-cell lymphotropic virus type-1(HTLV-1) contributes disproportionately to the burden of HTLV-1 associated diseases. All preventive measures to avoid MTCT rely on the identification of infected mothers. However, the impact of pregnancy on HTLV-1 diagnosis has not been clearly assessed. Paired samples from 21 HTLV-1 infected women taken during pregnancy and while not pregnant were analysed by CMIA and PCR. The signal-to-cut-off values (S/CO) were higher during pregnancy than in the paired non-pregnant samples. HTLV-1 proviral load did not alter significantly by pregnant state. S/CO positively correlated with HTLV proviral load. Pregnancy does not impair the diagnosis of HTLV-1/2, by either immunological (CMIA) or molecular (qPCR/nPCR) tests.
Identifiants
pubmed: 31513603
doi: 10.1371/journal.pntd.0007736
pii: PNTD-D-19-00684
pmc: PMC6764679
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0007736Subventions
Organisme : Department of Health
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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