Benzodiazepine use and brain amyloid load in nondemented older individuals: a florbetapir PET study in the Multidomain Alzheimer Preventive Trial cohort.

Alzheimer Disease / metabolism Amyloidogenic Proteins / metabolism Benzodiazepines / administration & dosage Brain / diagnostic imaging Cohort Studies Humans Positron-Emission Tomography
Alzheimer's disease Amyloid Benzodiazepine Florbetapir GABA-A Positron emission tomography

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
12 2019
Historique:
received: 05 03 2019
revised: 09 08 2019
accepted: 09 08 2019
pubmed: 13 9 2019
medline: 7 8 2020
entrez: 13 9 2019
Statut: ppublish

Résumé

It remains unclear whether benzodiazepines (BZDs) constitute a risk factor for Alzheimer's disease (AD). In this study, we investigated associations between chronic use of BZDs and brain amyloid load, a hallmark of AD, in 268 nondemented older individuals. F

Identifiants

DOI: 10.1016/j.neurobiolaging.2019.08.008 PMID: 31514054
pubmed: 31514054
pii: S0197-4580(19)30286-6
doi: 10.1016/j.neurobiolaging.2019.08.008
pii:
doi:

Substances chimiques

Amyloidogenic Proteins 0
Benzodiazepines 12794-10-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

61-69

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Thomas Desmidt (T)

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France; CHU de Tours, Tours, France. Electronic address: t.desmidt@chu-tours.fr.

Julien Delrieu (J)

Department of Geriatrics, Gérontopôle, CHU Toulouse, Purpan University Hospital, Toulouse, France; UMR1027, Université de Toulouse, UPS, INSERM, Toulouse, France.

Thibaud Lebouvier (T)

University of Lille, Inserm U1171, CHU, DistalZ, Lille, France.

Gabriel Robert (G)

Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France; Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.

Renaud David (R)

Department of Psychiatry, Memory Research and Resources Center, CHU Nice, Nice, France.

Anna-Chloé Balageas (AC)

CHU de Tours, Tours, France.

Alexandre Surget (A)

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Catherine Belzung (C)

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Nicolas Arlicot (N)

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France; INSERM CIC 1415, Université de Tours, Tours, France; CHRU de Tours, Unité de Radiopharmacie, Tours, France.

Maria-Joao Ribeiro (MJ)

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France; CHU de Tours, Tours, France; INSERM CIC 1415, Université de Tours, Tours, France.

Pierre Payoux (P)

UMR 1214, Toulouse Neuroimaging Center, University of Toulouse III, Toulouse, France; Department of Nuclear Medicine, University Hospital of Toulouse (CHU Toulouse), Toulouse, France.

Bruno Vellas (B)

Department of Geriatrics, Gérontopôle, CHU Toulouse, Purpan University Hospital, Toulouse, France; UMR1027, Université de Toulouse, UPS, INSERM, Toulouse, France.

Wissam El-Hage (W)

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France; CHU de Tours, Tours, France; INSERM CIC 1415, Université de Tours, Tours, France.

Elsa Tavernier (E)

CHU de Tours, Tours, France; INSERM CIC 1415, Université de Tours, Tours, France.

Vincent Camus (V)

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France; CHU de Tours, Tours, France.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Benzodiazepine use and brain amyloid load in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Protéines amyloïdogènes › Benzodiazepine use and brain amyloid load in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazepine use and brain amyloid load in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Benzodiazepine use and brain amyloid load in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Benzodiazepine use and brain amyloid load in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Benzodiazepine use and brain amyloid load in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Benzodiazepine use and brain amyloid load in...