The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans.
Immunomodulation
cytokines
inflammation
pregnancy
renal
Journal
Seminars in nephrology
ISSN: 1558-4488
Titre abrégé: Semin Nephrol
Pays: United States
ID NLM: 8110298
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
entrez:
14
9
2019
pubmed:
14
9
2019
medline:
19
5
2020
Statut:
ppublish
Résumé
The extent of the systemic inflammatory response following infectious or noninfectious insults is related to impaired patient outcome. Pregnancy is associated with immunotolerance and an increased glomerular filtration rate. EA-230 is a newly developed synthetic linear tetrapeptide derived from the "pregnancy hormone" human chorionic gonadotropin. In this review, we describe the immunomodulatory and renoprotective properties of EA-230 in preclinical animal models, phase 1 studies in humans and phase 2a studies performed during human experimental endotoxemia. In addition, details pertaining to the design of a recently completed phase 2b study in 180 patients who underwent cardiac surgery to investigate the safety and immunomodulatory and renoprotective properties of EA-230 are discussed.
Identifiants
pubmed: 31514913
pii: S0270-9295(19)30062-2
doi: 10.1016/j.semnephrol.2019.06.009
pii:
doi:
Substances chimiques
Oligopeptides
0
alanyl-glutaminyl-glycyl-valine
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
496-504Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.