Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics.

Aldehyde Dehydrogenase / antagonists & inhibitors Animals Enzyme Inhibitors / pharmacology Humans Neoplasms / drug therapy
aldehyde dehydrogenase cancer pharmacology cancer resistance cancer stem cells cancer therapy targeted inhibitors

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
10 2019
Historique:
received: 13 04 2019
revised: 29 07 2019
accepted: 08 08 2019
pubmed: 14 9 2019
medline: 7 7 2020
entrez: 14 9 2019
Statut: ppublish

Résumé

Aldehyde dehydrogenases (ALDHs) are highly expressed in the chemotherapy- and radiotherapy-resistant cell subpopulations of many different cancer types. Accordingly, the development of ALDH inhibitors may be the most direct approach to target these cell populations. However, inhibiting multiple ALDH family members can be toxic and isoform-specific inhibition is often ineffective. This review discusses the role of ALDH in cancer and therapy resistance, and then overviews the various available ALDH inhibitors with a focus on the clinical potential and limitations of these agents as cancer therapeutics. Finally, challenges and future research directions to effectively target ALDH in the management of cancer therapy resistance are discussed.

Identifiants

DOI: 10.1016/j.tips.2019.08.002 PMID: 31515079
pubmed: 31515079
pii: S0165-6147(19)30185-3
doi: 10.1016/j.tips.2019.08.002
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Aldehyde Dehydrogenase EC 1.2.1.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

774-789

Informations de copyright

Copyright © 2019. Published by Elsevier Ltd.

Auteurs

Saketh S Dinavahi (SS)

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Penn State Melanoma and Skin Cancer Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Christopher G Bazewicz (CG)

Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Penn State Melanoma and Skin Cancer Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Raghavendra Gowda (R)

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Penn State Melanoma and Skin Cancer Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Penn State Melanoma Therapeutics Program, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Foreman Foundation for Melanoma Research, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Gavin P Robertson (GP)

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Penn State Melanoma and Skin Cancer Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Penn State Melanoma Therapeutics Program, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Foreman Foundation for Melanoma Research, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address: gpr11@psu.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Aldehyde dehydrogenase › Aldehyde Dehydrogenase Inhibitors for Cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Aldehyde Dehydrogenase Inhibitors for Cancer...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Aldehyde Dehydrogenase Inhibitors for Cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aldehyde Dehydrogenase Inhibitors for Cancer...
questionsmedicales.fr › Tumeurs › Aldehyde Dehydrogenase Inhibitors for Cancer...