Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.
Amaryllidaceae
/ chemistry
Amaryllidaceae Alkaloids
/ chemistry
Antiprotozoal Agents
/ chemistry
Diterpenes
/ chemistry
Drug Evaluation, Preclinical
Humans
Isoquinolines
/ chemistry
Molecular Structure
Phytochemicals
/ chemistry
Plant Extracts
/ chemistry
Structure-Activity Relationship
Trypanosoma brucei brucei
/ drug effects
Alkaloid
Amaryllidaceae
Antiparasitic
Antiprotozoal
Medicinal plant
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
08
07
2019
revised:
23
08
2019
accepted:
24
08
2019
pubmed:
14
9
2019
medline:
23
10
2020
entrez:
14
9
2019
Statut:
ppublish
Résumé
Protozoan-borne diseases are prominent amongst diseases caused by parasites. Given their alarming morbidity and mortality statistics, there is ever growing interest in new therapies against these diseases. Whilst synthetic drugs such as benznidazole and melarsoprol have had a profound influence on the clinical setup, there has been significant interest in the phytochemical platform to also deliver such drug candidates. The plant family Amaryllidaceae is recognizable for its isoquinoline alkaloids, which exhibit attractive molecular architectures and interesting biological properties. This survey focuses on the antiprotozoal activities of 73 of such substances described in 18 different species of the Amaryllidaceae. Of these, 2-O-acetyllycorine was identified as the most potent (IC
Identifiants
pubmed: 31515186
pii: S0960-894X(19)30587-6
doi: 10.1016/j.bmcl.2019.126642
pii:
doi:
Substances chimiques
2-O-acetylorochrine
0
Amaryllidaceae Alkaloids
0
Antiprotozoal Agents
0
Diterpenes
0
Isoquinolines
0
Phytochemicals
0
Plant Extracts
0
isoquinoline
JGX76Y85M6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
126642Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.