Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein.
ARNTL Transcription Factors
/ chemistry
Amino Acid Sequence
Animals
Binding Sites
CREB-Binding Protein
/ chemistry
Circadian Clocks
Histone-Lysine N-Methyltransferase
/ chemistry
Mice
Mutagenesis, Site-Directed
Myeloid-Lymphoid Leukemia Protein
/ chemistry
Protein Binding
Protein Domains
Protein Structure, Secondary
Protein Structure, Tertiary
Proto-Oncogene Proteins c-myb
/ chemistry
Recombinant Proteins
/ biosynthesis
Scattering, Small Angle
Surface Plasmon Resonance
X-Ray Diffraction
BMAL1 G-region
CREB-binding protein (CBP)
SAXS
biophysics
brain and muscle ARNT-like protein-1 (BMAL1)
chromatin modification
circadian clock
circadian gene regulation
gene regulation
kinase inducible domain interacting (KIX) domain of CBP
protein interactions
structural biology
transactivation domain (TAD)
transcription regulation
transcriptional rhythmicity
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 11 2019
08 11 2019
Historique:
received:
18
06
2019
revised:
30
08
2019
pubmed:
14
9
2019
medline:
9
6
2020
entrez:
14
9
2019
Statut:
ppublish
Résumé
The mammalian CLOCK:BMAL1 transcription factor complex and its coactivators CREB-binding protein (CBP)/p300 and mixed-lineage leukemia 1 (MLL1) critically regulate circadian transcription and chromatin modification. Circadian oscillations are regulated by interactions of BMAL1's C-terminal transactivation domain (TAD) with the KIX domain of CBP/p300 (activating) and with the clock protein CRY1 (repressing) as well as by the BMAL1 G-region preceding the TAD. Circadian acetylation of Lys
Identifiants
pubmed: 31515273
pii: S0021-9258(20)30509-3
doi: 10.1074/jbc.RA119.009845
pmc: PMC6851309
doi:
Substances chimiques
ARNTL Transcription Factors
0
Proto-Oncogene Proteins c-myb
0
Recombinant Proteins
0
Myeloid-Lymphoid Leukemia Protein
149025-06-9
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
Kmt2a protein, mouse
EC 2.1.1.43
CREB-Binding Protein
EC 2.3.1.48
Banques de données
PDB
['4I9O', '2LXS']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16604-16619Informations de copyright
© 2019 Garg et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with the contents of this article.
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