Associations of plasma, RBCs, and hair carbon and nitrogen isotope ratios with fish, meat, and sugar-sweetened beverage intake in a 12-wk inpatient feeding study.
biomarkers
carbon isotope
food intake
nitrogen isotope
stable isotopes
Journal
The American journal of clinical nutrition
ISSN: 1938-3207
Titre abrégé: Am J Clin Nutr
Pays: United States
ID NLM: 0376027
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
27
02
2019
accepted:
31
07
2019
pubmed:
14
9
2019
medline:
3
4
2020
entrez:
14
9
2019
Statut:
ppublish
Résumé
Naturally occurring carbon and nitrogen stable isotope ratios [13C/12C (CIR) and 15N/14N (NIR)] are promising dietary biomarkers. As these candidate biomarkers have long tissue residence times, long-term feeding studies are needed for their evaluation. Our aim was to evaluate plasma, RBCs, and hair CIR and NIR as biomarkers of fish, meat, and sugar-sweetened beverage (SSB) intake in a 12-wk dietary intervention. Thirty-two men (aged 46.2 ± 10.5 y; BMI: 27.2 ± 4.0 kg/m2) underwent a 12-wk inpatient dietary intervention at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in Phoenix, Arizona. The effects of fish, meat, and SSB intake on CIR and NIR were evaluated using a balanced factorial design, with each intake factor at 2 levels (present/absent) in a common, background diet (50% carbohydrate, 30% fat, 20% protein). Fasting blood samples were taken biweekly from baseline, and hair samples were collected at baseline and postintervention. Data were analyzed using multivariable regression. The postintervention CIR of plasma was elevated when diets included meat (β = 0.89, 95% CI: 0.73,1.05) and SSBs (β = 0.48, 95% CI: 0.32, 0.64). The postintervention NIR of plasma was elevated when diets included fish (β = 0.85, 95% CI: 0.64, 1.05) and meat (β = 0.61, 95% CI: 0.42, 0.8). Results were similar for RBCs and hair. Postintervention RBC CIR and NIR had strong associations with baseline, suggesting that turnover to the intervention diets was incomplete after 12 wk. Estimates of isotopic turnover rate further confirmed incomplete turnover of RBCs. CIR was associated with meat and SSBs, and more strongly with meat. NIR was associated with fish and meat, and more strongly with fish. Overall, CIR and NIR discriminated between dietary fish and meat, and to a lesser extent SSBs, indicating their potential utility as biomarkers of intake in US diets. Approaches to make these biomarkers more specific are needed. This trial was registered at clinicaltrials.gov as NCT01237093.
Sections du résumé
BACKGROUND
Naturally occurring carbon and nitrogen stable isotope ratios [13C/12C (CIR) and 15N/14N (NIR)] are promising dietary biomarkers. As these candidate biomarkers have long tissue residence times, long-term feeding studies are needed for their evaluation.
OBJECTIVE
Our aim was to evaluate plasma, RBCs, and hair CIR and NIR as biomarkers of fish, meat, and sugar-sweetened beverage (SSB) intake in a 12-wk dietary intervention.
METHODS
Thirty-two men (aged 46.2 ± 10.5 y; BMI: 27.2 ± 4.0 kg/m2) underwent a 12-wk inpatient dietary intervention at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in Phoenix, Arizona. The effects of fish, meat, and SSB intake on CIR and NIR were evaluated using a balanced factorial design, with each intake factor at 2 levels (present/absent) in a common, background diet (50% carbohydrate, 30% fat, 20% protein). Fasting blood samples were taken biweekly from baseline, and hair samples were collected at baseline and postintervention. Data were analyzed using multivariable regression.
RESULTS
The postintervention CIR of plasma was elevated when diets included meat (β = 0.89, 95% CI: 0.73,1.05) and SSBs (β = 0.48, 95% CI: 0.32, 0.64). The postintervention NIR of plasma was elevated when diets included fish (β = 0.85, 95% CI: 0.64, 1.05) and meat (β = 0.61, 95% CI: 0.42, 0.8). Results were similar for RBCs and hair. Postintervention RBC CIR and NIR had strong associations with baseline, suggesting that turnover to the intervention diets was incomplete after 12 wk. Estimates of isotopic turnover rate further confirmed incomplete turnover of RBCs.
CONCLUSIONS
CIR was associated with meat and SSBs, and more strongly with meat. NIR was associated with fish and meat, and more strongly with fish. Overall, CIR and NIR discriminated between dietary fish and meat, and to a lesser extent SSBs, indicating their potential utility as biomarkers of intake in US diets. Approaches to make these biomarkers more specific are needed. This trial was registered at clinicaltrials.gov as NCT01237093.
Identifiants
pubmed: 31515553
pii: S0002-9165(22)01326-0
doi: 10.1093/ajcn/nqz208
pmc: PMC6885477
doi:
Substances chimiques
Carbon Isotopes
0
Nitrogen Isotopes
0
Banques de données
ClinicalTrials.gov
['NCT01237093']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1306-1315Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM103325
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109946
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Published by Oxford University Press on behalf of the American Society for Nutrition 2019.
Références
Arch Intern Med. 2009 Mar 23;169(6):562-71
pubmed: 19307518
Genes Nutr. 2018 May 30;13:14
pubmed: 29861790
Am J Clin Nutr. 1991 Sep;54(3):464-70
pubmed: 1877501
Br J Nutr. 2014 Jun 14;111(11):2032-43
pubmed: 24635904
Physiol Biochem Zool. 2011 Sep-Oct;84(5):506-13
pubmed: 21897087
Public Health Nutr. 2017 Jan;20(1):25-29
pubmed: 27297740
J Am Diet Assoc. 2011 Jun;111(6):874-8
pubmed: 21616200
Philos Trans R Soc Lond B Biol Sci. 1999 Jan 29;354(1379):65-75; discussion 75-6
pubmed: 10091248
Rapid Commun Mass Spectrom. 2015 Aug 15;29(15):1448-56
pubmed: 26147485
Meat Sci. 2015 Nov;109:86-95
pubmed: 26043666
Am J Clin Nutr. 1995 Oct;62(4):730-4
pubmed: 7572700
Proc Nutr Soc. 2016 Aug;75(3):227-32
pubmed: 26643369
J Nutr. 2015 Jun;145(6):1362-9
pubmed: 25855120
Obesity (Silver Spring). 2018 Apr;26(4):689-695
pubmed: 29504262
Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6
pubmed: 12835281
Rapid Commun Mass Spectrom. 2009 Aug 30;23(16):2411-20
pubmed: 19603474
Stat Med. 1996 Feb 28;15(4):361-87
pubmed: 8668867
J Nutr. 2013 Jun;143(6):878-84
pubmed: 23616504
Am J Phys Anthropol. 2006 Sep;131(1):137-46
pubmed: 16552735
Am J Epidemiol. 2010 Nov 1;172(9):1045-52
pubmed: 20817784
Circulation. 2016 Jan 26;133(4):370-7
pubmed: 26755505
Annu Rev Nutr. 2015;35:565-94
pubmed: 26048703
Obesity (Silver Spring). 2017 Feb;25(2):332-337
pubmed: 28000375
Am J Hum Biol. 2018 May;30(3):e23103
pubmed: 29388286
J Nutr. 2005 Jun;135(6):1515-20
pubmed: 15930462
Public Health Nutr. 2017 Jul;20(10):1738-1745
pubmed: 27465921
J Nutr. 2012 Jan;142(1):84-90
pubmed: 22157543
Integr Comp Biol. 2014 Nov;54(5):890-902
pubmed: 25104856
Rapid Commun Mass Spectrom. 2009 Aug 30;23(16):2448-54
pubmed: 19603471
Diabetes Care. 2003 Jan;26 Suppl 1:S33-50
pubmed: 12502618
Am J Phys Anthropol. 2013 Sep;152(1):58-66
pubmed: 23921599
J Nutr. 2010 Feb;140(2):333-7
pubmed: 20018804
J Acad Nutr Diet. 2014 Mar;114(3):444-9
pubmed: 24321742
Hum Genet. 2009 Jun;125(5-6):507-25
pubmed: 19357868
J Nutr. 2013 Feb;143(2):161-5
pubmed: 23256142
J Nutr. 2014 Jan;144(1):75-80
pubmed: 24198311
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17855-60
pubmed: 19001276
Annu Rev Public Health. 2016;37:273-93
pubmed: 26989829
Br J Nutr. 2017 Jun;117(11):1523-1530
pubmed: 28721839
Am J Clin Nutr. 2006 Dec;84(6):1380-4
pubmed: 17158420
Am J Hum Biol. 2017 Sep 10;29(5):null
pubmed: 28568975
Am J Clin Nutr. 2017 Jun;105(6):1462-1473
pubmed: 28446499
Eur J Nutr. 2013 Feb;52(1):389-95
pubmed: 22406837
Physiol Meas. 2014 May;35(5):739-51
pubmed: 24671094
Isotopes Environ Health Stud. 2017 Aug;53(4):356-367
pubmed: 28292192
Public Health Nutr. 2016 Feb;19(3):429-36
pubmed: 25901966
J Nutr. 2018 Dec 1;148(12):1931-1937
pubmed: 30239866
Am J Clin Nutr. 2009 Dec;90(6):1642-7
pubmed: 19864410
Am J Clin Nutr. 2014 Aug;100(2):708-18
pubmed: 24990425