MRI-Derived Biomarkers Related to Sarcopenia: A Systematic Review.
biomarkers
magnetic resonance imaging
prognosis
quantitative MRI
sarcopenia
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
21
05
2019
revised:
13
08
2019
accepted:
15
08
2019
pubmed:
14
9
2019
medline:
20
5
2021
entrez:
14
9
2019
Statut:
ppublish
Résumé
MRI allows quantitatively assessing muscle quantity and quality. To summarize the role of MRI as a noninvasive technique for the identification of in vivo surrogate biomarker of sarcopenia. Systematic review. In April 2019, a systematic literature search (Medline/EMBASE) was performed to identify articles on the topic at issue. No field strength or sequence restrictions. After a literature search, study design, aim, sample size, demographics, magnetic field strength, imaged body region, MRI sequences, and imaging biomarker were extracted. Data are presented as frequencies and percentages. From 69 records identified through search query, 18 articles matched the inclusion criteria. All articles were published from 2012 and had a mainly prospective design (14/18, 78%). Sample size ranged from 9 to 284 subjects, for a total of 1706 enrolled subjects. Healthy subjects were enrolled or retrospectively selected in 8/18 (44%) articles, corresponding to 658 (39%) healthy subjects. Magnetic field strength was 1.5 or 3T in 14/18 (78%) studies. The most analyzed body regions were the thigh (7/18, 39%) and the trunk (6/18, 33%). Stratifying studies according to their aim, 13/18 (72%) studies focused on muscle quality and quantity, 3/18 (17%) studies on outcome prediction, and 2/18 articles (11%) addressed both aims. A wide set of MRI biomarkers have been proposed. Muscle cross-sectional area was the most used for muscle quantity estimation, while quantitative biomarkers of muscle fat content or fiber architecture were proposed to assess muscle quality. The proposed biomarkers were assessed using different MRI sequences for different body regions in different subjects/patient cohorts, pointing out a lack of standardization on this topic. Future studies should test and compare the performance of proposed MRI biomarkers for sarcopenia characterization and quantification using a standardized experimental setup. 1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:1117-1127.
Sections du résumé
BACKGROUND
MRI allows quantitatively assessing muscle quantity and quality.
PURPOSE
To summarize the role of MRI as a noninvasive technique for the identification of in vivo surrogate biomarker of sarcopenia.
STUDY TYPE
Systematic review.
POPULATION
In April 2019, a systematic literature search (Medline/EMBASE) was performed to identify articles on the topic at issue.
FIELD STRENGTH/SEQUENCE
No field strength or sequence restrictions.
ASSESSMENT
After a literature search, study design, aim, sample size, demographics, magnetic field strength, imaged body region, MRI sequences, and imaging biomarker were extracted.
STATISTICAL TESTS
Data are presented as frequencies and percentages.
RESULTS
From 69 records identified through search query, 18 articles matched the inclusion criteria. All articles were published from 2012 and had a mainly prospective design (14/18, 78%). Sample size ranged from 9 to 284 subjects, for a total of 1706 enrolled subjects. Healthy subjects were enrolled or retrospectively selected in 8/18 (44%) articles, corresponding to 658 (39%) healthy subjects. Magnetic field strength was 1.5 or 3T in 14/18 (78%) studies. The most analyzed body regions were the thigh (7/18, 39%) and the trunk (6/18, 33%). Stratifying studies according to their aim, 13/18 (72%) studies focused on muscle quality and quantity, 3/18 (17%) studies on outcome prediction, and 2/18 articles (11%) addressed both aims. A wide set of MRI biomarkers have been proposed. Muscle cross-sectional area was the most used for muscle quantity estimation, while quantitative biomarkers of muscle fat content or fiber architecture were proposed to assess muscle quality.
DATA CONCLUSION
The proposed biomarkers were assessed using different MRI sequences for different body regions in different subjects/patient cohorts, pointing out a lack of standardization on this topic. Future studies should test and compare the performance of proposed MRI biomarkers for sarcopenia characterization and quantification using a standardized experimental setup.
LEVEL OF EVIDENCE
1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:1117-1127.
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1117-1127Informations de copyright
© 2019 International Society for Magnetic Resonance in Medicine.
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