Evaluation of bone formation using recombinant human bone morphogenetic proteins-7 in small maxillofacial bony defects.
Cysts
maxillofacial bony defects
recombinant human bone morphogenetic protein-7
Journal
Journal of oral and maxillofacial pathology : JOMFP
ISSN: 0973-029X
Titre abrégé: J Oral Maxillofac Pathol
Pays: India
ID NLM: 101227995
Informations de publication
Date de publication:
Historique:
entrez:
14
9
2019
pubmed:
14
9
2019
medline:
14
9
2019
Statut:
ppublish
Résumé
Bone morphogenetic proteins (BMP) are multifunctional molecules of transforming growth factor-β superfamily that induces the differentiation of fibroblasts into osteoblasts to form bone. This study was undertaken to evaluate the effects of recombinant human BMP-7 (rhBMP-7) in bone healing of small maxillofacial bone defects and assess the serum levels of osteopontin (OPN) and receptor activator of nuclear factor kappa-B ligand (RANKL) biomarkers for bone remodeling. Twenty patients with small maxillofacial bony defects were enrolled in this study and randomly allocated to two groups; wherein after apicoectomy of the involved teeth, the control group had defect filled with collagen sponge only while the experimental group had rhBMP-7 impregnated collagen sponge placed in the defect. The clinical parameters showed no significant difference between the two groups ( This study confirms that rhBMP-7 in collagen definitely accelerates bone healing in maxillofacial bone defects and minimizes postoperative complications. RANKL and OPN biomarkers in serum may not show bone remodeling, hence tissue samples may be used to assess their levels.
Identifiants
pubmed: 31516225
doi: 10.4103/jomfp.JOMFP_292_18
pii: JOMFP-23-208
pmc: PMC6714274
doi:
Types de publication
Journal Article
Langues
eng
Pagination
208-212Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Int J Periodontics Restorative Dent. 1997 Feb;17(1):11-25
pubmed: 10332250
J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S151-8
pubmed: 11314793
J Biol Chem. 1992 Oct 5;267(28):20352-62
pubmed: 1328198
Lancet. 2004 Aug 28-Sep 3;364(9436):766-70
pubmed: 15337402
Injury. 2005 Nov;36 Suppl 3:S28-33
pubmed: 16188546
Mol Reprod Dev. 1992 Jun;32(2):160-7
pubmed: 1637554
Oral Dis. 2006 Nov;12(6):514-22
pubmed: 17054762
Eur Arch Otorhinolaryngol. 2007 Nov;264(11):1343-56
pubmed: 17628823
Oral Dis. 2010 Nov;16(8):709-16
pubmed: 20534013
Br J Oral Maxillofac Surg. 2011 Oct;49(7):507-9
pubmed: 21144628
Curr Opin Otolaryngol Head Neck Surg. 2011 Apr;19(2):119-24
pubmed: 21358547
Ann Plast Surg. 2011 Dec;67(6):655-61
pubmed: 21825966
Adv Drug Deliv Rev. 2012 Sep;64(12):1277-91
pubmed: 22512928
Br J Oral Maxillofac Surg. 2014 Jan;52(1):7-15
pubmed: 23601833
Science. 1988 Dec 16;242(4885):1528-34
pubmed: 3201241
J Hand Surg Am. 1986 May;11(3):417-9
pubmed: 3711617
J Dent Res. 1971 Nov-Dec;50(6):1392-406
pubmed: 4943222
Science. 1965 Nov 12;150(3698):893-9
pubmed: 5319761
Biochem Biophys Res Commun. 1993 Dec 30;197(3):1253-9
pubmed: 8280141
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83
pubmed: 8570652
J Periodontol. 1998 Feb;69(2):129-37
pubmed: 9526911