Status of VEGF in preeclampsia and its effect on endoplasmic reticulum stress in placental trophoblast cells.
ER stress
Preeclampsia
UPR
VEGF
Journal
European journal of obstetrics & gynecology and reproductive biology: X
ISSN: 2590-1613
Titre abrégé: Eur J Obstet Gynecol Reprod Biol X
Pays: Netherlands
ID NLM: 101750520
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
05
01
2019
revised:
18
05
2019
accepted:
11
06
2019
entrez:
14
9
2019
pubmed:
14
9
2019
medline:
14
9
2019
Statut:
epublish
Résumé
To explore the role of VEGF in attenuating endoplasmic reticulum stress in placental trophoblast cells. Study was divided into following parts: 1. Serum Analysis of GRP78 and VEGF using sandwich ELISA. 2. Expression of VEGF and GRP78 in placentae by immunohistochemistry (IHC). 3. Increased GRP78 and decreased VEGF protein levels in sera and placentae of preeclamptic pregnant women and reduced expression of various ER stress markers at both transcript and protein levels was observed in trophoblast cells when they were exposed to recombinant VEGF thereby indicating positive role of VEGF in alleviating ER stress. Reduced expression of ER stress markers in trophoblast cells against increased VEGF highlighted a new window to explore prospective drugs that can be designed to modulate the activities of various ER stress sensors in order to alleviate ER stress in pregnant women with preeclampsia.
Identifiants
pubmed: 31517301
doi: 10.1016/j.eurox.2019.100070
pii: S2590-1613(19)30103-6
pii: 100070
pmc: PMC6728727
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100070Références
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