Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke.
Airway Resistance
/ physiology
Animals
Bronchi
/ cytology
Cells, Cultured
Ceramides
/ metabolism
Epithelial Cells
Gene Expression Regulation
/ drug effects
Humans
Macrophages
/ metabolism
Matrix Metalloproteinases
/ biosynthesis
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Phosphorylation
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-akt
/ metabolism
Pulmonary Disease, Chronic Obstructive
/ metabolism
Smoke
/ adverse effects
Sphingomyelins
/ biosynthesis
Nicotiana
/ adverse effects
Tobacco Products
/ adverse effects
Transferases (Other Substituted Phosphate Groups)
/ biosynthesis
Akt phosphorylation
airway restriction
cigarette smoke
protease
sphingomyelin synthase
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
14
9
2019
medline:
28
7
2020
entrez:
14
9
2019
Statut:
ppublish
Résumé
Sphingomyelin synthase is responsible for the production of sphingomyelin (SGM), the second most abundant phospholipid in mammalian plasma, from ceramide, a major sphingolipid. Knowledge of the effects of cigarette smoke on SGM production is limited. In the present study, we examined the effect of chronic cigarette smoke on sphingomyelin synthase (SGMS) activity and evaluated how the deficiency of
Identifiants
pubmed: 31517509
doi: 10.1165/rcmb.2019-0133OC
pmc: PMC7055695
doi:
Substances chimiques
Ceramides
0
Smoke
0
Sphingomyelins
0
AKT1 protein, human
EC 2.7.11.1
Akt1 protein, mouse
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
SGMS2 protein, human
EC 2.7.8.-
Sgms1 protein, mouse
EC 2.7.8.-
Transferases (Other Substituted Phosphate Groups)
EC 2.7.8.-
Sgms2 protein, mouse
EC 2.7.8.27
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
342-353Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL139365
Pays : United States
Commentaires et corrections
Type : CommentIn
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