Quantification of Myocardial Mass Subtended by a Coronary Stenosis Using Intracoronary Physiology.
Aged
Blood Flow Velocity
Cardiac Catheterization
Computed Tomography Angiography
Coronary Angiography
Coronary Artery Disease
/ diagnosis
Coronary Circulation
Coronary Stenosis
/ diagnosis
Coronary Vessels
/ diagnostic imaging
Energy Metabolism
Feasibility Studies
Female
Humans
Japan
Male
Middle Aged
Models, Biological
Myocardium
/ metabolism
Netherlands
Oxygen Consumption
Predictive Value of Tests
Reproducibility of Results
blood flow velocity
computed tomography angiography
coronary circulation
coronary stenosis
myocardium
Journal
Circulation. Cardiovascular interventions
ISSN: 1941-7632
Titre abrégé: Circ Cardiovasc Interv
Pays: United States
ID NLM: 101499602
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
entrez:
14
9
2019
pubmed:
14
9
2019
medline:
9
6
2020
Statut:
ppublish
Résumé
In patients with stable coronary artery disease, the amount of myocardium subtended by coronary stenoses constitutes a major determinant of prognosis, as well as of the benefit of coronary revascularization. We devised a novel method to estimate partial myocardial mass (PMM; ie, the amount of myocardium subtended by a stenosis) during physiological stenosis interrogation. Subsequently, we validated the index against equivalent PMM values derived from applying the Voronoi algorithm on coronary computed tomography angiography. Based on the myocardial metabolic demand and blood supply, PMM was calculated as follows: PMM (g)=APV×D Median PMM was 15.8 g (Q1, Q3: 11.7, 28.4 g) for physiology-based PMM, and 17.0 g (Q1, Q3: 12.5, 25.9 g) for computed tomography-based PMM ( Physiology-based calculation of PMM in the catheterization laboratory is feasible and can be accurately performed as part of functional stenosis assessment.
Sections du résumé
BACKGROUND
In patients with stable coronary artery disease, the amount of myocardium subtended by coronary stenoses constitutes a major determinant of prognosis, as well as of the benefit of coronary revascularization. We devised a novel method to estimate partial myocardial mass (PMM; ie, the amount of myocardium subtended by a stenosis) during physiological stenosis interrogation. Subsequently, we validated the index against equivalent PMM values derived from applying the Voronoi algorithm on coronary computed tomography angiography.
METHODS
Based on the myocardial metabolic demand and blood supply, PMM was calculated as follows: PMM (g)=APV×D
RESULTS
Median PMM was 15.8 g (Q1, Q3: 11.7, 28.4 g) for physiology-based PMM, and 17.0 g (Q1, Q3: 12.5, 25.9 g) for computed tomography-based PMM (
CONCLUSIONS
Physiology-based calculation of PMM in the catheterization laboratory is feasible and can be accurately performed as part of functional stenosis assessment.
Identifiants
pubmed: 31518164
doi: 10.1161/CIRCINTERVENTIONS.118.007322
doi:
Types de publication
Journal Article
Multicenter Study
Validation Study
Langues
eng
Sous-ensembles de citation
IM