Design and Development of the Brain Training System for the Digital "Maintain Your Brain" Dementia Prevention Trial.
clinical trial design
computerized cognitive training
dementia
older adults
Journal
JMIR aging
ISSN: 2561-7605
Titre abrégé: JMIR Aging
Pays: Canada
ID NLM: 101740387
Informations de publication
Date de publication:
27 Feb 2019
27 Feb 2019
Historique:
received:
01
01
2019
accepted:
09
02
2019
revised:
05
02
2019
entrez:
14
9
2019
pubmed:
14
9
2019
medline:
14
9
2019
Statut:
epublish
Résumé
Dementia is the leading cause of disability worldwide, and interventions aimed at reducing the prevalence and burden of the disease are urgently needed. Maintain Your Brain (MYB) is a randomized controlled trial of a multimodal digital health intervention targeting modifiable dementia risk factors to combat cognitive decline and potentially prevent dementia. In addition to behavioral modules targeting mood, nutrition, and physical exercise, a new Brain Training System (BTS) will deliver computerized cognitive training (CCT) throughout the trial to provide systematic, challenging, and personally adaptive cognitive activity. This paper aimed to describe the design and development of BTS. BTS has been designed with a central focus on the end user. Raw training content is provided by our partner NeuroNation and delivered in several innovative ways. A baseline cognitive profile directs selection and sequencing of exercises within and between sessions and is updated during the 10-week 30-session module. Online trainers are available to provide supervision at different levels of engagement, including face-to-face share-screen coaching, a key implementation resource that is triaged by a "red flag" system for automatic tracking of user adherence and engagement, or through user-initiated help requests. Individualized and comparative feedback is provided to aid motivation and, for the first time, establish a social support network for the user based on their real-world circle of friends and family. The MYB pilot was performed from November 2017 to March 2018. We are currently analyzing data from this pilot trial (n=100), which will make up a separate research paper. The main trial was launched in June 2018. Process and implementation data from the first training module (September to November 2018) are expected to be reported in 2019 and final trial outcomes are anticipated in 2022. The BTS implemented in MYB is focused on maximizing adherence and engagement with CCT over the short and long term in the setting of a fully digital trial, which, if successful, could be delivered economically at scale. Australian New Zealand Clinical Trials Registry ACTRN12618000851268; https://www.anzctr.org.au /Trial/Registration/TrialReview.aspx?id=370631&isReview=true.
Sections du résumé
BACKGROUND
BACKGROUND
Dementia is the leading cause of disability worldwide, and interventions aimed at reducing the prevalence and burden of the disease are urgently needed. Maintain Your Brain (MYB) is a randomized controlled trial of a multimodal digital health intervention targeting modifiable dementia risk factors to combat cognitive decline and potentially prevent dementia. In addition to behavioral modules targeting mood, nutrition, and physical exercise, a new Brain Training System (BTS) will deliver computerized cognitive training (CCT) throughout the trial to provide systematic, challenging, and personally adaptive cognitive activity.
OBJECTIVE
OBJECTIVE
This paper aimed to describe the design and development of BTS.
METHODS
METHODS
BTS has been designed with a central focus on the end user. Raw training content is provided by our partner NeuroNation and delivered in several innovative ways. A baseline cognitive profile directs selection and sequencing of exercises within and between sessions and is updated during the 10-week 30-session module. Online trainers are available to provide supervision at different levels of engagement, including face-to-face share-screen coaching, a key implementation resource that is triaged by a "red flag" system for automatic tracking of user adherence and engagement, or through user-initiated help requests. Individualized and comparative feedback is provided to aid motivation and, for the first time, establish a social support network for the user based on their real-world circle of friends and family.
RESULTS
RESULTS
The MYB pilot was performed from November 2017 to March 2018. We are currently analyzing data from this pilot trial (n=100), which will make up a separate research paper. The main trial was launched in June 2018. Process and implementation data from the first training module (September to November 2018) are expected to be reported in 2019 and final trial outcomes are anticipated in 2022.
CONCLUSIONS
CONCLUSIONS
The BTS implemented in MYB is focused on maximizing adherence and engagement with CCT over the short and long term in the setting of a fully digital trial, which, if successful, could be delivered economically at scale.
TRIAL REGISTRATION
BACKGROUND
Australian New Zealand Clinical Trials Registry ACTRN12618000851268; https://www.anzctr.org.au /Trial/Registration/TrialReview.aspx?id=370631&isReview=true.
Identifiants
pubmed: 31518277
pii: v2i1e13135
doi: 10.2196/13135
pmc: PMC6715098
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e13135Informations de copyright
©Courtney Campbell Walton, Amit Lampit, Christos Boulamatsis, Harry Hallock, Polly Barr, Jeewani Anupama Ginige, Henry Brodaty, Tiffany Chau, Megan Heffernan, Perminder Singh Sachdev, Maria A Fiatarone Singh, Michael Valenzuela. Originally published in JMIR Aging (http://aging.jmir.org), 27.02.2019.
Références
Am Psychol. 2000 Jan;55(1):68-78
pubmed: 11392867
JAMA. 2002 Nov 13;288(18):2271-81
pubmed: 12425704
Int J Epidemiol. 2008 Oct;37(5):941-7
pubmed: 17881411
J Am Geriatr Soc. 2009 Apr;57(4):594-603
pubmed: 19220558
Restor Neurol Neurosci. 2009;27(5):455-71
pubmed: 19847070
Neuropsychol Rev. 2009 Dec;19(4):504-22
pubmed: 19876740
Nature. 2010 Jun 10;465(7299):775-8
pubmed: 20407435
Curr Psychiatry Rep. 2010 Feb;12(1):20-7
pubmed: 20425306
BMC Health Serv Res. 2011 Oct 14;11:273
pubmed: 21999305
BMJ Open. 2011 Nov 21;1(2):e000225
pubmed: 22106377
Front Aging Neurosci. 2014 Mar 17;6:43
pubmed: 24672478
Am J Psychiatry. 2014 May;171(5):510-22
pubmed: 24700194
Front Hum Neurosci. 2014 Apr 24;8:242
pubmed: 24795603
PLoS Med. 2014 Nov 18;11(11):e1001756
pubmed: 25405755
Behav Brain Res. 2015 Dec 15;295:64-70
pubmed: 25591472
Psychol Res. 2016 Mar;80(2):181-94
pubmed: 25716189
Psychon Bull Rev. 2016 Feb;23(1):324-30
pubmed: 26082279
J Affect Disord. 2016 Jan 1;189:184-91
pubmed: 26437233
Neurology. 2015 Nov 24;85(21):1843-51
pubmed: 26519540
Neuropsychol Rehabil. 2016 Oct;26(5-6):810-21
pubmed: 26674122
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7470-4
pubmed: 27325761
JMIR Serious Games. 2016 Jul 15;4(2):e11
pubmed: 27421244
J Neuroeng Rehabil. 2016 Oct 4;13(1):88
pubmed: 27716336
Am J Psychiatry. 2017 Apr 1;174(4):329-340
pubmed: 27838936
J Cogn Neurosci. 2017 Sep;29(9):1473-1482
pubmed: 27897677
J Alzheimers Dis. 2017;60(3):889-911
pubmed: 28922158
J Prev Alzheimers Dis. 2014;1(1):33-39
pubmed: 29261218
Res Nurs Health. 2018 Feb;41(1):11-18
pubmed: 29266286
Pain. 2018 Apr;159(4):644-655
pubmed: 29447133
JAMA Psychiatry. 2018 Jul 1;75(7):697-703
pubmed: 29847678
BMC Geriatr. 2018 Sep 15;18(1):213
pubmed: 30219036
J Alzheimers Dis. 2019;70(s1):S221-S237
pubmed: 30475762
Health Educ Q. 1988 Winter;15(4):351-77
pubmed: 3068205