An insight into analysis and elimination of plasmids encoding metallo-β-lactamases in Pseudomonas aeruginosa.
Anti-Bacterial Agents
/ pharmacology
Aztreonam
/ pharmacology
Cefotaxime
/ pharmacology
Cross Infection
/ microbiology
DNA Copy Number Variations
Drug Resistance, Multiple, Bacterial
Ertapenem
/ pharmacology
Gene Expression Regulation, Bacterial
/ drug effects
Humans
Imipenem
/ pharmacology
Meropenem
/ pharmacology
Microbial Sensitivity Tests
Plasmids
/ drug effects
Pseudomonas Infections
/ microbiology
Pseudomonas aeruginosa
/ drug effects
Sodium Dodecyl Sulfate
/ pharmacology
Suppuration
/ microbiology
Urine
/ microbiology
beta-Lactamases
/ genetics
Copy number
Curing
Metallo-β-lactamase
Plasmid
SDS
Journal
Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
28
07
2018
revised:
22
08
2019
accepted:
02
09
2019
pubmed:
14
9
2019
medline:
7
4
2021
entrez:
14
9
2019
Statut:
ppublish
Résumé
The aim of this study was to characterise metallo-β-lactamase (MBL)-harbouring plasmids, their change in copy number in respect to different antibiotic pressure, and the efficiency of different curing agents in eliminating these resistance plasmids from nosocomial Pseudomonas aeruginosa isolates. Plasmids were extracted from four isolates harbouring bla Conjugatively transferable MBL genes (bla The spread of multidrug resistance plasmids has been noted as a key factor associated with increasing carbapenem resistance. Successful curing of resistance plasmids can reverse the bacterial phenotype back to susceptible. This study revealed that different antibiotic pressure induces a change in copy number of MBL-encoding plasmids. SDS can be successfully used as an eliminating agent for these resistance determinants, although therapeutic application of this agent is not possible due to its high toxicity and mutagenic nature.
Identifiants
pubmed: 31518725
pii: S2213-7165(19)30234-6
doi: 10.1016/j.jgar.2019.09.002
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Sodium Dodecyl Sulfate
368GB5141J
Imipenem
71OTZ9ZE0A
beta-Lactamases
EC 3.5.2.6
Meropenem
FV9J3JU8B1
Aztreonam
G2B4VE5GH8
Ertapenem
G32F6EID2H
Cefotaxime
N2GI8B1GK7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-7Informations de copyright
Copyright © 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.