A novel self-organizing embryonic stem cell system reveals signaling logic underlying the patterning of human ectoderm.
BMP signaling
Ectoderm development
Human embryonic stem cells
Self-organization
WNT signaling
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
17 10 2019
17 10 2019
Historique:
received:
08
04
2019
accepted:
06
09
2019
pubmed:
15
9
2019
medline:
27
6
2020
entrez:
15
9
2019
Statut:
epublish
Résumé
During development, the ectoderm is patterned by a combination of BMP and WNT signaling. Research in model organisms has provided substantial insight into this process; however, there are currently no systems in which to study ectodermal patterning in humans. Further, the complexity of neural plate border specification has made it difficult to transition from discovering the genes involved to deeper mechanistic understanding. Here, we develop an
Identifiants
pubmed: 31519692
pii: dev.179093
doi: 10.1242/dev.179093
pmc: PMC6826045
pii:
doi:
Substances chimiques
BMP4 protein, human
0
Bone Morphogenetic Protein 4
0
Wnt Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM126122
Pays : United States
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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