Anticancer Effect of Deuterium Depleted Water - Redox Disbalance Leads to Oxidative Stress.
Chemoproteomics
anticancer
cancer therapeutics
deuterium depleted water
oxidative stress
proteomics
quantification
redox disbalance
tandem mass spectrometry
Journal
Molecular & cellular proteomics : MCP
ISSN: 1535-9484
Titre abrégé: Mol Cell Proteomics
Pays: United States
ID NLM: 101125647
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
01
04
2019
revised:
22
08
2019
pubmed:
15
9
2019
medline:
2
7
2020
entrez:
15
9
2019
Statut:
ppublish
Résumé
Despite the convincing empirical evidence that deuterium depleted water (DDW, 25-125 ppm deuterium) has anticancer effect, the molecular mechanism remains unclear. Here, redox proteomics investigation of the DDW action in A549 cells revealed an increased level of oxidative stress, whereas expression proteomics in combination with thermal profiling uncovered crucial role of mitochondrial proteins. In the proposed scenario, reversal of the normally positive deuterium gradient across the inner membrane leads to an increased export of protons from the matrix to intermembrane space and an increase in the mitochondrial membrane potential, enhancing the production of reactive oxygen species (ROS). The resulting oxidative stress leads to slower growth and can induce apoptosis. However, further deuterium depletion in ambient water triggers a feedback mechanism, which leads to restoration of the redox equilibrium and resumed growth. The DDW-induced oxidative stress, verified by traditional biochemical assays, may be helpful as an adjuvant to ROS-inducing anticancer therapy.
Identifiants
pubmed: 31519768
pii: S1535-9476(20)31643-1
doi: 10.1074/mcp.RA119.001455
pmc: PMC6885702
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Proteome
0
Reactive Oxygen Species
0
Water
059QF0KO0R
Deuterium
AR09D82C7G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2373-2387Informations de copyright
© 2019 Zhang et al.
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