Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 09 2019
13 09 2019
Historique:
received:
12
04
2019
accepted:
30
08
2019
entrez:
15
9
2019
pubmed:
15
9
2019
medline:
31
10
2020
Statut:
epublish
Résumé
Phosphoinositides (PIPs) participate in many cellular processes, including cancer progression; however, the metabolic features of PIPs associated with prostate cancer (PCa) are unknown. We investigated PIPs profiles in PTEN-deficient prostate cancer cell lines, human prostate tissues obtained from patients with PCa and benign prostate hyperplasia (BPH) specimens using mass spectrometry. In immortalized normal human prostate PNT1B cells, PTEN deficiency increased phosphatidylinositol tris-phosphate (PIP
Identifiants
pubmed: 31520002
doi: 10.1038/s41598-019-49744-3
pii: 10.1038/s41598-019-49744-3
pmc: PMC6744559
doi:
Substances chimiques
Phosphatidylinositol Phosphates
0
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13257Références
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