Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine.
Africa
Genetic risk score
Genome-wide association studies
Obesity
Precision medicine
Type 2 diabetes
Journal
Current diabetes reports
ISSN: 1539-0829
Titre abrégé: Curr Diab Rep
Pays: United States
ID NLM: 101093791
Informations de publication
Date de publication:
14 09 2019
14 09 2019
Historique:
entrez:
15
9
2019
pubmed:
15
9
2019
medline:
15
4
2020
Statut:
epublish
Résumé
Recent advances in genomics provide opportunities for novel understanding of the biology of human traits with the goal of improving human health. Here, we review recent obesity and type 2 diabetes (T2D)-related genomic studies in African populations and discuss the implications of limited genomics studies on health disparity and precision medicine. Genome-wide association studies in Africans have yielded genetic discovery that would otherwise not be possible; these include identification of novel loci associated with obesity (SEMA-4D, PRKCA, WARS2), metabolic syndrome (CA-10, CTNNA3), and T2D (AGMO, ZRANB3). ZRANB3 was recently demonstrated to influence beta cell mass and insulin response. Despite these promising results, genomic studies in African populations are still limited and thus genomics tools and approaches such as polygenic risk scores and precision medicine are likely to have limited utility in Africans with the unacceptable possibility of exacerbating prevailing health disparities. African populations provide unique opportunities for increasing our understanding of the genetic basis of cardiometabolic disorders. We highlight the need for more coordinated and sustained efforts to increase the representation of Africans in genomic studies both as participants and scientists.
Identifiants
pubmed: 31520154
doi: 10.1007/s11892-019-1215-5
pii: 10.1007/s11892-019-1215-5
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105Subventions
Organisme : Intramural NIH HHS
ID : Z01 HG200362
Pays : United States
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