Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Aged
Aged, 80 and over
Alzheimer Disease
/ metabolism
Animals
Brain
/ ultrastructure
Disease Models, Animal
Female
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Tissue Proteins
/ classification
Nitric Oxide
/ metabolism
Nitric Oxide Synthase Type II
/ metabolism
Proteomics
/ methods
Signal Transduction
Synaptosomes
/ chemistry
Alzheimer’s disease
S-nitrosylation
mass spectrometry
neuroinflammation
synaptosome
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
25
04
2019
revised:
23
08
2019
accepted:
04
09
2019
pubmed:
15
9
2019
medline:
28
8
2020
entrez:
15
9
2019
Statut:
ppublish
Résumé
Increasing evidence suggests that both synaptic loss and neuroinflammation constitute early pathologic hallmarks of Alzheimer's disease. A downstream event during inflammatory activation of microglia and astrocytes is the induction of nitric oxide synthase type 2, resulting in an increased release of nitric oxide and the post-translational S-nitrosylation of protein cysteine residues. Both early events, inflammation and synaptic dysfunction, could be connected if this excess nitrosylation occurs on synaptic proteins. In the long term, such changes could provide new insight into patho-mechanisms as well as biomarker candidates from the early stages of disease progression. This study investigated S-nitrosylation in synaptosomal proteins isolated from APP/PS1 model mice in comparison to wild type and NOS2
Substances chimiques
Nerve Tissue Proteins
0
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type II
EC 1.14.13.39
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
710-726Subventions
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Informations de copyright
© 2019 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
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