Alpha synuclein deficiency increases CD4
Animals
CD4-Positive T-Lymphocytes
/ immunology
Cell Proliferation
Encephalomyelitis, Autoimmune, Experimental
/ immunology
Female
Gene Expression Regulation
Gene Silencing
Inflammation
/ immunology
Lymphocyte Activation
/ physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Multiple Sclerosis
/ immunology
Nuclear Receptor Subfamily 4, Group A, Member 2
/ genetics
Th1 Cells
/ immunology
alpha-Synuclein
/ deficiency
CD4 + T cells
Nurr1
alpha synuclein
multiple sclerosis
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
23
05
2019
revised:
05
09
2019
accepted:
10
09
2019
pubmed:
15
9
2019
medline:
1
7
2020
entrez:
15
9
2019
Statut:
ppublish
Résumé
It has been suggested that extracellular alpha synuclein (αSyn) can mediate neuroinflammation in Parkinson's disease, and that αSyn affects B-cell maturation. However, the function of αSyn in T cells is poorly understood. We hypothesized that αSyn can affect CD4
Substances chimiques
Nr4a2 protein, mouse
0
Nuclear Receptor Subfamily 4, Group A, Member 2
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
61-71Informations de copyright
© 2019 International Society for Neurochemistry.
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