Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP.

Animals Deoxycytidine Monophosphate / analogs & derivatives Enzyme Inhibitors / metabolism Fluorodeoxyuridylate / metabolism Folic Acid / analogs & derivatives Mice Protein Binding Spectrophotometry, Ultraviolet Tetrahydrofolates / metabolism Thymidylate Synthase / metabolism
5-Fluorodeoxyuridylate binding Dihydrofolate production Inactivation Tetrahydrofolate-dependent Thymidylate synthase

Journal

Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430

Informations de publication

Date de publication:
15 10 2019
Historique:
received: 27 07 2019
revised: 08 09 2019
accepted: 10 09 2019
pubmed: 15 9 2019
medline: 9 4 2020
entrez: 15 9 2019
Statut: ppublish

Résumé

In view of previous crystallographic studies, N

Identifiants

DOI: 10.1016/j.abb.2019.108106 PMID: 31520592
pubmed: 31520592
pii: S0003-9861(19)30606-X
doi: 10.1016/j.abb.2019.108106
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Tetrahydrofolates 0
Deoxycytidine Monophosphate 1032-65-1
Fluorodeoxyuridylate 134-46-3
N-4-hydroxy-2'-deoxycytidylic acid 2277-58-9
dihydrofolate 4033-27-6
5,6,7,8-tetrahydrofolic acid 43ZWB253H4
Folic Acid 935E97BOY8
Thymidylate Synthase EC 2.1.1.45

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108106

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Justyna Sobich (J)

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland.

Małgorzata Prokopowicz (M)

Warsaw University, College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, and Faculty of Physics, Warszawa, Poland.

Piotr Maj (P)

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland.

Piotr Wilk (P)

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland.

Zbigniew Zieliński (Z)

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland.

Tomasz Frączyk (T)

Medical University of Warsaw, Department of Immunology, Transplantology and Internal Medicine, Warszawa, Poland.

Wojciech Rode (W)

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland. Electronic address: w.rode@nencki.gov.pl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Nucléotides pyrimidiques › Nucléotides désoxycytidyliques › Désoxycytidine monophosphate › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Nucléotides pyrimidiques › Nucléotides désoxyuridyliques › Désoxyfluorouridylate › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Acide folique › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie UV › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › Tétrahydrofolates › Thymidylate synthase-catalyzed,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Thymidylate synthase › Thymidylate synthase-catalyzed,...