Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.
African American
Exacerbations
admixture
ancestry
asthma
black
ethnic group
genetics
lung function
race
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
19
04
2019
revised:
27
07
2019
accepted:
16
08
2019
pubmed:
15
9
2019
medline:
9
6
2020
entrez:
15
9
2019
Statut:
ppublish
Résumé
Minority groups of African descent experience disproportionately greater asthma morbidity compared with other racial groups, suggesting that genetic variation from a common ancestry could influence exacerbation risk. We evaluated clinical trial measures in the context of self-reported race and genetic ancestry to identify risk factors for asthma exacerbations. One thousand eight hundred forty multiethnic subjects from 12 Asthma Clinical Research Network and AsthmaNet trials were analyzed for incident asthma exacerbations with Poisson regression models that included clinical measures, self-reported race (black, non-Hispanic white, and other), and estimates of global genetic African ancestry in a subgroup (n = 760). Twenty-four percent of 1840 subjects self-identified as black. Black and white subjects had common risk factors for exacerbations, including a history of 2 or more exacerbations in the previous year and FEV Black subjects have unique risk factors for asthma exacerbations, of which global African genetic ancestry had the strongest effect.
Sections du résumé
BACKGROUND
Minority groups of African descent experience disproportionately greater asthma morbidity compared with other racial groups, suggesting that genetic variation from a common ancestry could influence exacerbation risk.
OBJECTIVE
We evaluated clinical trial measures in the context of self-reported race and genetic ancestry to identify risk factors for asthma exacerbations.
METHODS
One thousand eight hundred forty multiethnic subjects from 12 Asthma Clinical Research Network and AsthmaNet trials were analyzed for incident asthma exacerbations with Poisson regression models that included clinical measures, self-reported race (black, non-Hispanic white, and other), and estimates of global genetic African ancestry in a subgroup (n = 760).
RESULTS
Twenty-four percent of 1840 subjects self-identified as black. Black and white subjects had common risk factors for exacerbations, including a history of 2 or more exacerbations in the previous year and FEV
CONCLUSION
Black subjects have unique risk factors for asthma exacerbations, of which global African genetic ancestry had the strongest effect.
Identifiants
pubmed: 31520679
pii: S0091-6749(19)31180-7
doi: 10.1016/j.jaci.2019.08.033
pmc: PMC6931257
mid: NIHMS1544332
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1524-1533Subventions
Organisme : NHLBI NIH HHS
ID : U10 HL098107
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL118128
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098075
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098102
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098115
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098103
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142992
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098098
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098096
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI125785
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL109250
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098177
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098090
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL098112
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Références
N Engl J Med. 2010 Oct 28;363(18):1715-26
pubmed: 20979471
Genet Epidemiol. 2013 May;37(4):393-401
pubmed: 23554133
J Allergy Clin Immunol. 2017 Jul;140(1):257-265.e11
pubmed: 28069248
JAMA. 2014 May;311(20):2083-91
pubmed: 24838406
Lancet Respir Med. 2013 Oct;1(8):599-609
pubmed: 24461663
Vital Health Stat 3. 2012 Nov;(35):1-58
pubmed: 24252609
Am J Hum Genet. 2007 Jun;80(6):1171-8
pubmed: 17503334
Am J Respir Crit Care Med. 2007 Feb 1;175(3):228-34
pubmed: 16973987
J Allergy Clin Immunol. 2015 Mar;135(3):655-62
pubmed: 25617226
JAMA. 2012 Sep 12;308(10):987-97
pubmed: 22968888
Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313
pubmed: 27556234
J Allergy Clin Immunol. 2011 Jun;127(6):1457-65
pubmed: 21397937
Eur Respir J. 2005 Nov;26(5):812-8
pubmed: 16264041
Am J Hum Genet. 2015 Jan 8;96(1):37-53
pubmed: 25529636
Ann Allergy Asthma Immunol. 2008 Sep;101(3):256-63
pubmed: 18814448
Respir Med. 2006 Feb;100(2):273-8
pubmed: 15998585
J Allergy Clin Immunol. 2012 Dec;130(6):1302-6
pubmed: 23069492
J Allergy Clin Immunol. 2015 Jan;135(1):228-35
pubmed: 25301036
JAMA. 2015 Oct 27;314(16):1720-30
pubmed: 26505596
Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):504-9
pubmed: 10673193
Curr Allergy Asthma Rep. 2015 Apr;15(4):16
pubmed: 26130473
J Allergy Clin Immunol. 2002 Mar;109(3):410-8
pubmed: 11897984
J Allergy Clin Immunol. 2010 Oct;126(4):747-53
pubmed: 20920764
Am J Respir Crit Care Med. 2007 Apr 15;175(8):783-90
pubmed: 17204725
N Engl J Med. 2005 Apr 14;352(15):1519-28
pubmed: 15829533
Hum Genet. 2009 Jun;125(5-6):565-79
pubmed: 19290544
JAMA. 2001 May 23-30;285(20):2594-603
pubmed: 11368733
J Allergy Clin Immunol. 2018 Feb;141(2):754-760.e3
pubmed: 28535964
BMJ Open. 2018 Mar 22;8(3):e020825
pubmed: 29567854
Lancet. 2009 Nov 21;374(9703):1754-64
pubmed: 19932356
J Allergy Clin Immunol. 1998 May;101(5):594-601
pubmed: 9600494
Chest. 2005 Feb;127(2):571-8
pubmed: 15705998
N Engl J Med. 2010 Jul 22;363(4):321-30
pubmed: 20647190
Am J Respir Crit Care Med. 2011 Dec 1;184(11):1247-53
pubmed: 21885625
J Allergy Clin Immunol. 2007 Jan;119(1):14-21; quiz 22-3
pubmed: 17208583
JAMA. 2018 Oct 16;320(15):1531-1532
pubmed: 30264132
Lancet. 2004 Oct 23-29;364(9444):1505-12
pubmed: 15500895
PLoS One. 2012;7(1):e26807
pubmed: 22235241
Am J Respir Crit Care Med. 2014 Aug 1;190(3):266-73
pubmed: 24937318
J Allergy Clin Immunol. 2014 Jan;133(1):16-26
pubmed: 24369795
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Thorax. 2012 May;67(5):450-5
pubmed: 22514237
JAMA. 2018 Oct 16;320(15):1533-1534
pubmed: 30264136
Am J Respir Crit Care Med. 2015 Oct 1;192(7):899-902
pubmed: 26426787
JAMA. 2001 May 23-30;285(20):2583-93
pubmed: 11368732
Chest. 2005 May;127(5):1579-86
pubmed: 15888831
Respir Res. 2001;2(1):53-60
pubmed: 11686864
Lancet Respir Med. 2014 Mar;2(3):204-13
pubmed: 24621682
J Asthma. 2019 Jul;56(7):704-710
pubmed: 29969928
J Allergy Clin Immunol. 2012 Jun;129(6):1484-90.e6
pubmed: 22560959