A case of high altitude cutaneous leishmaniasis in a non-endemic region in Nepal.

Adult Altitude Antiprotozoal Agents / therapeutic use Humans Leishmania donovani / isolation & purification Leishmaniasis, Cutaneous / diagnosis Male Nepal Skin / parasitology Treatment Outcome
Cutaneous Leishmaniasis Leishmania donovani complex Nepal

Journal

Parasitology international
ISSN: 1873-0329
Titre abrégé: Parasitol Int
Pays: Netherlands
ID NLM: 9708549

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 04 02 2019
revised: 21 08 2019
accepted: 09 09 2019
pubmed: 15 9 2019
medline: 14 3 2020
entrez: 15 9 2019
Statut: ppublish

Résumé

A case of cutaneous leishmaniasis was discovered in a 32-year old man with a persistent erythematous plaque. The patient resides in a high altitude (~2000 m above sea level) area that is not endemic for cutaneous leishmaniasis in the Dunai village of Dolpa, Nepal. The patient's lesion was initially misdiagnosed as lupus vulgaris. After response failure to initial treatment, additional testing by histological microscopy revealed the presence of Leishmania amastigotes in tissue from the lesion, and the diagnosis of cutaneous leishmaniasis was confirmed by nested PCR DNA assay of tissue from the lesion, and by a positive rK39 test in blood. Sequencing of the kinetoplast region confirmed the presence of Leishmania donovani complex. The patient responded well to treatments for cutaneous leishmaniasis and the skin lesions regressed after 6 months. This is the first known case of cutaneous leishmaniasis in a patient in Nepal who resides at high altitude in a non-endemic region. Increasing temperatures in this region of Nepal may be expanding the range of vectors that transmit cutaneous leishmaniasis.

Identifiants

DOI: 10.1016/j.parint.2019.101991 PMID: 31520692
pubmed: 31520692
pii: S1383-5769(19)30342-3
doi: 10.1016/j.parint.2019.101991
pii:
doi:

Substances chimiques

Antiprotozoal Agents 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101991

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Anup Bastola (A)

Sukraraj Tropical & Infectious Disease Hospital, Kathmandu, Nepal.

Mitesh Shrestha (M)

Central Department of Biotechnology, Tribhuvan University, Nepal; Research Institute for Bioscience and Biotechnology, Nepal. Electronic address: mitesh@biotechtu.edu.np.

Mahesh Lamsal (M)

Central Department of Biotechnology, Tribhuvan University, Nepal.

Srijan Shrestha (S)

Central Department of Biotechnology, Tribhuvan University, Nepal.

Sabita Prajapati (S)

Central Department of Biotechnology, Tribhuvan University, Nepal.

Anurag Adhikari (A)

Central Department of Biotechnology, Tribhuvan University, Nepal.

Birendra Prasad Gupta (BP)

Central Department of Biotechnology, Tribhuvan University, Nepal.

Mallorie Hide (M)

Maladies infectieusesetvecteurs: écologie, génétique, évolution et contrôle, UMR (IRD/CNRS/UM), 5290 Montpellier, France. Electronic address: mallorie.hide@ird.fr.

Lina Devkota (L)

Sukraraj Tropical & Infectious Disease Hospital, Kathmandu, Nepal.

Bimal Sharma Chalise (BS)

Sukraraj Tropical & Infectious Disease Hospital, Kathmandu, Nepal.

Kishor Pandey (K)

Molecular Biotechnology Unit, Nepal Academy of Science and Technology, Nepal.

Krishna Das Manandhar (KD)

Central Department of Biotechnology, Tribhuvan University, Nepal. Electronic address: krishna.manandhar@biotechtu.edu.np.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A case of high altitude cutaneous...
questionsmedicales.fr › Environnement et santé publique › Environnement › Altitude › A case of high altitude cutaneous...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › A case of high altitude cutaneous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A case of high altitude cutaneous...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Leishmania donovani › A case of high altitude cutaneous...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Dermatoses parasitaires › Leishmaniose › Leishmaniose cutanée › A case of high altitude cutaneous...
questionsmedicales.fr › Régions géographiques › Asie › Asie de l'Ouest › Asie du Sud › Népal › A case of high altitude cutaneous...
questionsmedicales.fr › Système tégumentaire › Peau › A case of high altitude cutaneous...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › A case of high altitude cutaneous...